Lifeboat Foundation

Microglial cells are the maintenance workers of the central nervous system (CNS), protecting against pathogens and pruning damaged neurons to help the brain maintain homeostasis. Considered immune cells, microglia work to protect the brain from before it is fully formed through its lifetime, but they aren’t infallible. The cells can be primed early on to respond in certain ways, making the microglia’s clean-up efforts less efficient. As other cells age, they can complicate microglial function, making them less effective.

But the underlying mechanism of how microglial cells age and how their aging directly affects the brain is poorly understood—meaning that attempts to prevent or treat brain dysfunction may not be as effective as they could be, according to a multi-institutional collaboration led by Bo Peng and Yanxia Rao, both professors at Fudan University.

The team investigated how microglial cells change as they age in both male and female mice across their lifespans, finding what the researchers called “unexpected sex differences.” They also established a model to study aged microglial cells in a non-aged brain, revealing that aged-like microglia contribute to cognitive decline even in young mice. The researchers published their findings in Nature Aging.

Scientists established an epigenetic mouse model for glioma, providing insight into how epigenetics can initiate cancer.

A study in the journal Cell sheds new light on the evolution of neurons, focusing on the placozoans, a millimeter-sized marine animal. Researchers at the Center for Genomic Regulation in Barcelona find evidence that specialized secretory cells found in these unique and ancient creatures may have given rise to neurons in more complex animals.

Placozoans are tiny animals, around the size of a large grain of sand, which graze on algae and microbes living on the surface of rocks and other substrates found in shallow, warm seas. The blob-like and pancake-shaped creatures are so simple that they live without any body parts or organs.

Continue reading “Tiny sea creatures reveal the ancient origins of neurons” »

Elon Musk’s neurotech startup announced that it is now seeking patients with paralysis to test a brain-computer interface.

Integrated information theory is seen by some people as a leading theory of consciousness, but now over 100 neuroscientists have signed an open letter calling it untestable pseudoscience.

By Clare Wilson

Scientists at Université Laval and the University of Lethbridge have succeeded in reversing certain cognitive manifestations associated with Alzheimer’s disease in an animal model of the disease. Their results have been published in the scientific journal Brain.

Although this has yet to be demonstrated in humans, we believe that the mechanism we have uncovered constitutes a very interesting therapeutic target, because it not only slows down the progression of the disease but also partially restores certain cognitive functions.

Summary: The revolutionary field of bio-computing is making waves as DishBrain, a neural system combining 800,000 living brain cells, learns to play Pong. Recognizing the pressing need for ethical guidelines in this emerging domain, the pioneers behind DishBrain have joined forces with bioethicists in a study.

The research explores the moral considerations around biological computing systems and their potential consciousness. Beyond its innovation, the technology offers vast environmental benefits, potentially transforming the energy-consuming IT industry.

From the oxygen-carrying corpuscles in our blood to the branching neurons that govern our thoughts, our body is built of a dazzling variety of cells.

Researchers from institutions in Germany, Canada, Spain, and the US have published a comprehensive study of how many individual cells of each type there are in typical bodies.

Based on an exhaustive analysis of over 1,500 published sources, most adult males contain a total of around 36 trillion cells, while adult females tend to have some 28 trillion cells. A 10-year-old child, by comparison, would have in the region of 17 trillion.

Pigs with human kidneys? Brain-powered computer chips? Science is creating new kinds of living things – and our moral understanding needs to catch up fast.