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Category: neuroscience – Page 320

A Scanner Darkly.
by Philip K. Dick.
Read by Gary Telles.
Originally issued by NLS on cassette in 1994
I guess I’ll come back on Thursday.
This is a pretty good alternative to Paul Giamatti’s narration.
“In a near-future, drug-ridden America, narcotics agent Bob Arctor goes undercover to catch a drug dealer. In the junkie culture in which he operates (even his girlfriend is a dealer), he takes large doses of a drug that splits his brain into two separate personalities. The agent has no knowledge of his other self, who, as it turns out, is the drug dealer he is after.“
00:00:00 — (i) Book info.
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Like these books? Want to help?
These books come from the National Library Services.
I encourage you to donate:
https://www.loc.gov/nls/about/donate/

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The bioactivity of most near-infrared II (NIRII) fluorophores are limited, thereby conflicting the achievement of strong fluorescence and high catalytic activities, due to a lack of free electrons in the method.

To overcome this challenge, Huizhen Ma and a research team in translational medicine, , physics, and materials at the Tianjin University China developed atomically precise gold clusters with strong near-infrared II fluorescence to show potent enzyme-mimetic activities by using atomic engineering, to form active copper single-atom sites.

These gold-copper clusters (Au21 Cu1) showed higher antioxidant nature with a 90-fold catalase-like and 3-fold higher superoxide dismutase-like activity compared to gold clusters alone. These clusters can be cleared through the to monitor cisplatin-induced within a 20–120-minute window to visualize the process in 3D via near-infrared light-sheet microscopy.

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Short-lived proteins control gene expression in cells and execute critical roles ranging from assisting brain connectivity to fortifying the body’s immune response. Originating in the nucleus, these proteins are swiftly degraded after fulfilling their purpose.

For decades, the mechanism behind the degradation and removal of these essential proteins from cells remained a mystery to researchers — until now.

In a cross-departmental collaboration, researchers from Harvard Medical School identified a protein called midnolin that plays a key role in degrading many short-lived nuclear proteins. The study shows that midnolin does so by directly grabbing the proteins and pulling them into the cellular waste-disposal system, called the proteasome, where they are destroyed.

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Get my new Longevity Practices book for free: https://www.diamandis.com/longevity.

In this episode, filmed during Abundance360, Peter and David discuss David’s groundbreaking research on reversing aging through epigenetic changes, emphasizing that aging is not just damage to the body but a loss of information. They talk about age reversal as a possibility, rejuvenating brains, and regaining lost memories.

David Sinclair is a biologist and academic known for his expertise in aging and epigenetics. Sinclair is a genetics professor and the Co-Director of Harvard Medical School’s Paul F. Glenn Center for Biology of Aging Research. He’s been included in Time100 as one of the 100 Most Influential People in the World, and his research has been featured all over the media. Besides writing a New York Times Best Seller, David has co-founded several biotech companies, a science publication called Aging, and is an inventor of 35 patents.

Read Sinclair’s latest study, Chemically Induced Reprogramming to Reverse Cellular Aging: https://www.aging-us.com/article/204896/text.

Learn about Abundance360: https://www.abundance360.com/

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Continue reading “Aging is Now Optional w/ David Sinclair | EP #60” | >

Vaccinations against tetanus and diphtheria, pneumococcus, and herpes zoster (HZ)- better known as shingles, are linked to a reduced risk of Alzheimer’s disease (AD). The corresponding study was published in the Journal of Alzheimer’s Disease.

Viral, bacterial, and fungal infections increase the risk of neuroinflammation, which may cause or exacerbate neurodegeneration and dementia. Vaccines may thus reduce neurodegeneration and dementia risk by reducing the risk of infection. Previous research, for example, shows that people who receive at least one influenza vaccine are 40% less likely than unvaccinated peers to develop AD.

Currently, the Centers for Disease Control and Prevention (CDC) Advisory Committee on Immunization Practices (ACIP) recommends older adults receive vaccines against tetanus, diphtheria and herpes zoster, and pneumococcus. The researchers behind the current study thus sought to see how these common vaccines may affect AD risk.

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Most of us who’ve reached middle age have noticed a slowing in memory and cognition, but scientists don’t have a clear picture of the molecular changes that take place in the brain to cause it.

Now, a study in mice has determined that the most pronounced changes occur in the white matter, a type of nervous system tissue that’s integral to transmitting signals across the brain. The study also examined two treatments — caloric restriction and infusions of plasma from young mice — that affect certain regions of the brain, with the plasma appearing to slow the age-related decline.

The results offer insight into the cognitive decline of normal aging, as well as the way aging contributes to neurodegenerative conditions such as Alzheimer’s and Parkinson’s diseases and multiple sclerosis.

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How looks life with na implant in brain.

Brain-computer interface technology is a fast-growing field but how does it feel to live with an implant inside of you?

In 2014, Ian Burkhart looked down at his hand and imagined closing it. To his astonishment, his hand did just that.

This was the first time a paraplegic person had regained the ability to move his arm by the sheer force of his thought, assisted by an implant in his brain.

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The viral ALS Ice Bucket Challenge a few years ago raised major funding that resulted in the discovery of new genes connected to the disease. One of those genes is NEK1, in which mutations have been linked to as much as 2% of all ALS cases, making it one of the top-known causes of the disease.

But it wasn’t known how the mutated gene disrupts the function of the motor neuron and causes it to degenerate and die.

Northwestern Medicine scientists have discovered for the first time how this mutated gene leads to ALS (amyotrophic lateral sclerosis).

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