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To capture a broader understanding of memory encoding, we expanded our experiments to include two other stimulus types: colors and face pictures (see Materials and Methods). Both monkeys demonstrated high accuracy in memorizing grating orientations in the “orientation DMTS” task, colors in the “color DMTS” task, and face pictures in the “face DMTS” task [DP: ~94% and DQ: ~87% versus 50%, all P < 0.01 (one-sample t test)] (fig. S1), indicating that they had been well trained.

We implanted a Utah array in each monkey’s V1 area (see Materials and Methods; Fig. 1B) and presented the stimuli onto the receptive field (RF) centers of the recorded neurons (fig. S2, A and D). This enabled simultaneous monitoring of neuronal activity in our experiments. Our analyses focused primarily on neuronal activity before probe stimulus onset.

Representative neuronal responses for two of the VWM content conditions in the orientation DMTS task at a selected electrode are shown in Fig. 1C. During the stimulus period (0 to 200 ms after cue onset), neurons displayed distinct firing patterns between the two content conditions (90° or 180° orientation). An off-response emerged following the cue offset, and activity gradually diminished. During the delay period, defined as 700 to 1,700 ms after cue onset (the thick gray line in Fig. 1C), neurons also exhibited a significant difference in firing rate between the two content conditions (N = 1,810 trials for 90°; N = 1,865 trials for 180°; all marked positions P < 0.01) without any behavioral performance bias (N = 16 sessions, P = 0.94; right panel in Fig. 1C). The difference in response between these two content conditions during the delay period at the same electrode was less prominent in incorrect-response trials and in the fixation task (Fig. 1D).

Brain-on-a-chip models, mimicking brain physiology, hold promise for developing treatments for neurological disorders. This Review discusses the engineering challenges and opportunities for these devices, including the integration of 3D cell cultures and electrodes and scaffold engineering strategies.

Daiki Nishioka and colleagues show a nanodevice implementation of deep reservoir computing using an ion-gating reservoir, achieving record-low error rates on a complex computational task. This device is more efficient and scalable for brain-like computing systems exploiting physical systems.

One of the ambitions of computational neuroscience is that we will continue to make improvements in the field of artificial intelligence that will be informed by advances in our understanding of how the brains of various species evolved to process information. To that end, here the authors propose an expanded version of the Turing test that involves embodied sensorimotor interactions with the world as a new framework for accelerating progress in artificial intelligence.

Beaubois et al. introduce a real-time biomimetic neural network for biohybrid experiments, providing a tool to study closed-loop applications for neuroscience and neuromorphic-based neuroprostheses.

Nearly all the neural networks that power modern artificial intelligence tools such as ChatGPT are based on a 1960s-era computational model of a living neuron. A new model developed at the Flatiron Institute’s Center for Computational Neuroscience (CCN) suggests that this decades-old approximation doesn’t capture all the computational abilities that real neurons possess and that this older model is potentially holding back AI development.

A UK teenager with severe epilepsy has become the first person in the world to be fitted with a brain implant aimed at bringing seizures under control.

Oran Knowlson’s neurostimulator sits under the skull and sends electrical signals deep into the brain, reducing his daytime seizures by 80%.

His…

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Research in nonhuman primates is opening the possibility of testing treatments for the early stages of Alzheimer’s and similar diseases, before extensive brain cell death and dementia set in. A study published in Alzheimer’s & Dementia shows up to a six-month window in which disease progress could be tracked and treatments tested in rhesus macaques.

This study identifies a small molecule (TAC) that restores physiological levels of TERT throughout aged tissues, resulting in the rejuvenation of multiple tissues. Specifically, TAC administration in very aged mice alleviates multiple aging hallmarks such as cellular senescence and systemic inflammation, promotes new neuron formation with improved cognitive ability, enhances neuromuscular function, and is well tolerated with no evidence of toxicity.