Lifeboat Foundation

I remember the #DotCom crash all too well.

The publication record of health-care start-up companies doesn’t seem to matter to investors, according to an analysis of nearly 50 biomedical ‘unicorns’ — venture-capital-backed companies valued at more than US$1 billion. The analysis, led by health-policy researcher John Ioannidis at Stanford University in California, finds no correlation between a company’s market valuation and its publication record — defined as the number of peer-reviewed papers authored directly by a firm. That’s a cause for concern, the authors say.

Firms can achieve fêted ‘unicorn’ valuations without publishing much peer-reviewed science. Health-care start-ups can reach billion-dollar valuations without publishing in peer-reviewed journals, but skipping that step can catch them out.

Oxfam’s director of campaigns and policy, Matthew Spencer, said: The massive fall in the number of people living in extreme poverty is one of the greatest achievements of the past quarter of a century but rising inequality is jeopardising further progress.

It said the widening gap was hindering the fight against poverty, adding that a wealth tax on the 1% would raise an estimated $418bn (£325bn) a year – enough to educate every child not in school and provide healthcare that would prevent 3 million deaths.

As Beijing’s pilot reform spreads nationwide to cut prices of drugs and improve their efficacy and safety, companies are under mounting pressure to invest in innovative drugs development and reduce reliance on low profit products that are the same copies of original drugs.

New policy environment demanding cheaper drugs adds pressure to innovate.

CERN has revealed plans for a gigantic successor of the giant atom smasher LHC, the biggest machine ever built. Particle physicists will never stop to ask for ever larger big bang machines. But where are the limits for the ordinary society concerning costs and existential risks?

CERN boffins are already conducting a mega experiment at the LHC, a 27km circular particle collider, at the cost of several billion Euros to study conditions of matter as it existed fractions of a second after the big bang and to find the smallest particle possible – but the question is how could they ever know? Now, they pretend to be a little bit upset because they could not find any particles beyond the standard model, which means something they would not expect. To achieve that, particle physicists would like to build an even larger “Future Circular Collider” (FCC) near Geneva, where CERN enjoys extraterritorial status, with a ring of 100km – for about 24 billion Euros.

Experts point out that this research could be as limitless as the universe itself. The UK’s former Chief Scientific Advisor, Prof Sir David King told BBC: “We have to draw a line somewhere otherwise we end up with a collider that is so large that it goes around the equator. And if it doesn’t end there perhaps there will be a request for one that goes to the Moon and back.”

“There is always going to be more deep physics to be conducted with larger and larger colliders. My question is to what extent will the knowledge that we already have be extended to benefit humanity?”

Continue reading “Why it is dangerous to build ever larger big bang machines” »

A Lunar Industrial Facility (LIF). Yes, a Lunar Industrial Facility. Science fiction you might say. Impossible you retort. Too expensive even if it could be done might be your rejoinder. We don’t have the technology, could be another rhetorical dismissal. These are all responses those who do not live and breath this every day may have, but these are reactionary responses that do not reflect where we are in the closing years of the second decade of the twenty first century. In this missive, which is a companion to a space policy paper released Monday August 1, 2017, is written to show that indeed a lunar industrial facility is possible, we do have the technology, and no it will not be too expensive. Furthermore, it enables something that though it would seem to be science fiction, isn’t, which is a shipyard in lunar orbit for the construction of humanities first truly interplanetary space vehicles, as well as providing the materials for very large Earth orbiting space platforms for science and commerce.

Why do we need interplanetary vehicles? We have over 9.1 billion reasons, for that is the number of humans who will be on the Earth in 2050, only 33 years from now. The greatest fear is that with only a single planet’s resources, we cannot provide for this number in any reasonable manner. This underpins most of the rhetoric today regarding resource conservation and how to confront other global problems. This is a self defeating philosophy. Rather than rationing poverty, it should be our common goal to help create a world where all of our fellow planetary citizens can live in a society that continues to progress, materially as well as morally. Our science knows beyond any shadow of a doubt now that resources many orders of magnitude greater than what are available from the Earth, exist in the solar system around us.

As the new year begins, we approach one of the most awaited life extension events of 2019: the Undoing Aging conference.

Starting off with a success

The Undoing Aging conference series started off in 2018, with the first being held in Berlin, Germany, in mid-March. Especially when you consider that UA2018 was the inaugural event of the series, it was extremely successful; the three-day conference organized by SENS Research Foundation (SRF) and Forever Healthy Foundation (FHF) brought together many of the most illustrious experts in the fields of aging research, biotechnology, regenerative medicine, AI for drug discovery, advocacy and policy, and business and investment.

Continue reading “Anticipation Is Growing for Undoing Aging 2019” »

Scientists in Europe and the United States face an uncertain political landscape in the new year, which could affect funding and collaborations. The threat is most acute in the United Kingdom, which plans to exit the European Union in March but has not settled on the terms of its departure. Some big research findings could share the headlines, however, including the first clear images of the supermassive black hole at the heart of our galaxy, from astronomers in an international collaboration called the Event Horizon Telescope. Science’s news staff forecasts other areas of research and policy likely to make news this year.

Science’s news editors and writers predict this year’s biggest developments.

As an international relations scholar who studies space law and policy, I have come to realize what most people do not fully appreciate: Dealing with space debris is as much a national security issue as it is a technical one.

Considering the debris circling the Earth as just an obstacle in the path of human missions is naive. As outer space activities are deeply rooted in the geopolitics down on Earth, the hidden challenge posed by the debris is the militarization of space technologies meant to clean it up.

To be clear, space debris poses considerable risks; however, to understand those risks, I should explain what it is and how it is formed. The term “space debris” refers to defunct human-made objects, relics left over from activities dating back to the early days of the space age. Over time that definition has expanded to include big and small things like discarded boosters, retired satellites, leftover bits and pieces from spacecraft, screwdrivers, tools, nuts and bolts, shards, lost gloves, and even flecks of paint.

Continue reading “The Hidden Danger of Cleaning Up Our Space Junk” »

Supersonic air travel is back. 15 years after the Concorde was grounded, everyone from aerospace companies to NASA to small startups is working to bring back ultrafast civilian aircraft. We take a look at the engineering challenges that make supersonic flight so difficult, and try to figure out what’s different about this new generation of planes.

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Continue reading “Supersonic air travel is finally coming back” »