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At Oak Ridge National Laboratory (ORNL), quantum biology, artificial intelligence, and bioengineering have collided to redefine the landscape of CRISPR Cas9 genome editing tools. This multidisciplinary approach, detailed in the journal Nucleic Acids Research, promises to elevate the precision and efficiency of genetic modifications in organisms, particularly microbes, paving the way for enhanced production of renewable fuels and chemicals.

CRISPR is adept at modifying genetic code to enhance an organism’s performance or correct mutations. CRISPR Cas9 requires a guide RNA (gRNA) to direct the enzyme to its target site to perform these modifications. However, existing computational models for predicting effective guide RNAs in CRISPR tools have shown limited efficiency when applied to microbes. ORNL’s Synthetic Biology group, led by Carrie Eckert, observed these disparities and set out to bridge the gap.

“A lot of the CRISPR tools have been developed for mammalian cells, fruit flies, or other model species. Few have been geared towards microbes where the chromosomal structures and sizes are very different,” explained Eckert.

A controversial new electric propulsion system, which physicists say defies Newton’s Laws of Motion, was launched into space this weekend aboard a Space X rocket.

Developed by electronics prototyping company IVO Ltd, the Quantum Drive took flight Saturday morning, November 11^th, aboard SpaceX’s Transporter 9 mission. This flight included over 80 separate payloads destined for Low Earth Orbit (LEO).

“Launch and deployment were successful!” IVO’s owner and founder, Richard Mansell, told The Debrief in a Sunday email. “We’re getting the satellite’s ‘heartbeat.’ Next step is to establish communication with the satellite.”

The AI tools were complemented by quantum biology and bioengineering approaches.

Philip Gray/ORNL, U.S. Dept. of Energy.

Combining several advances.

Continue reading “AI improves genome editing of microbes to produce renewable fuels” »

Absolutely empty—that is how most of us envision the vacuum. Yet, in reality, it is filled with an energetic flickering: the quantum fluctuations.

Experts are currently preparing a laser experiment intended to verify these vacuum fluctuations in a novel way, which could potentially provide clues to new laws in physics. A research team from the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) has developed a series of proposals designed to help conduct the experiment more effectively—thus increasing the chances of success. The team presents its findings in Physical Review D.

The physics world has long been aware that the vacuum is not entirely void but is filled with vacuum fluctuations—an ominous quantum flickering in time and space. Although it cannot be captured directly, its influence can be indirectly observed, for example, through changes in the electromagnetic fields of tiny particles.

It can take years of focused laboratory work to determine how to make the highest quality materials for use in electronic and photonic devices. Researchers have now developed an autonomous system that can identify how to synthesize “best-in-class” materials for specific applications in hours or days.

The new system, called SmartDope, was developed to address a longstanding challenge regarding enhancing properties of materials called perovskite quantum dots via “doping.”

“These doped quantum dots are semiconductor nanocrystals that you have introduced specific impurities to in a targeted way, which alters their optical and physicochemical properties,” explains Milad Abolhasani, an associate professor of chemical engineering at North Carolina State University and corresponding author of the paper “Smart Dope: A Self-Driving Fluidic Lab for Accelerated Development of Doped Perovskite Quantum Dots,” published open access in the journal Advanced Energy Materials.

Generation of nearly deterministic OAM-based entangled states offers a bridge between photonic technologies for quantum advancements.

Quantum technology’s future rests on the exploitation of fascinating quantum mechanics concepts — such as high-dimensional quantum states. Think of these as states basic ingredients of quantum information science and quantum tech. To manipulate these states, scientists have turned to light, specifically a property called orbital angular momentum (OAM), which deals with how light twists and turns in space. Here’s a catch: making super bright single photons with OAM in a deterministic fashion has been a tough nut to crack.

Quantum Dots: Bridging Technologies

Deep within every piece of magnetic material, electrons dance to the invisible tune of quantum mechanics. Their spins, akin to tiny atomic tops, dictate the magnetic behavior of the material they inhabit. This microscopic ballet is the cornerstone of magnetic phenomena, and it’s these spins that a team of JILA researchers—headed by JILA Fellows and University of Colorado Boulder professors Margaret Murnane and Henry Kapteyn—has learned to control with remarkable precision, potentially redefining the future of electronics and data storage.

In a Science Advances publication, the JILA team—along with collaborators from universities in Sweden, Greece, and Germany—probed the spin dynamics within a special material known as a Heusler compound: a mixture of metals that behaves like a single magnetic material.

For this study, the researchers utilized a compound of cobalt, manganese, and gallium, which behaved as a conductor for electrons whose spins were aligned upwards and as an insulator for electrons whose spins were aligned downwards.

The way light interacts with naturally occurring materials is well-understood in physics and materials science. But in recent decades, researchers have fabricated metamaterials that interact with light in new ways that go beyond the physical limits imposed on naturally occurring materials.

A metamaterial is composed of arrays of “meta-atoms,” which have been fabricated into desirable structures on the scale of about a hundred nanometers. The structure of arrays of meta-atoms facilitate precise light-matter interactions. However, the large size of meta-atoms relative to regular atoms, which are smaller than a nanometer, has limited the performance of metamaterials for practical applications.

Now, a collaborative research team led by Bo Zhen of the University of Pennsylvania has unveiled a new approach that directly engineers atomic structures of material by stacking the two-dimensional arrays in spiral formations to tap into novel light-matter interaction. This approach enables metamaterials to overcome the current technical limitations and paves the way for next-generation lasers, imaging, and quantum technologies. Their findings were published in the journal Nature Photonics.

It started with a simple experiment that was all the rage in the early 20^th century. And as is usually the case, simple experiments often go on to change the world, leading Einstein himself to open the revolutionary door to the quantum world.

Here’s the setup. You take a piece of metal. You shine a light on it. You wait for the electrons in the metal to get enough energy from the light that they pop off the surface and go flying out. You point some electron-detector at the metal to measure the number and energy of the electrons.

Continue reading “How Einstein Unlocked the Quantum Universe and Created the Photon” »