Lifeboat Foundation

Circa 2021

With SpaceX continuing the testing phase for Starship and enthusiasm spreading for an actual crewed flight to Mars, an interesting magnetic thrust rocket concept conceived by physicist Fatima Ebrahimi at the US Department of Energy’s (DOE) Princeton Plasma Physics Laboratory (PPPL) might make the mission much more cost effective.

Continue reading “Physicist designs magnetic thrust engine that could rocket us to the Red Planet” »

SpaceX has successfully launched and landed the same Falcon 9 booster twice in three weeks, smashing the current record for orbital-class rocket turnaround.

The existing record was also held by Falcon 9 and set in early 2021 when booster B1060 launched a Turkish communications satellite and a batch of Starlink spacecraft just 27 days and 4 hours apart. Now, just under 15 months later, a new Falcon 9 booster has decisively taken the crown.

At 5:27 pm EDT, Falcon 9 B1062 lifted off as planned from SpaceX’s Cape Canaveral Space Force Station (CCSFS) Launch Complex 40 pad. Flying for the sixth time, the reused booster carried an expendable Falcon upper stage, fairing, and a batch of 53 Starlink V1.5 satellites most of the way out of Earth’s atmosphere to a velocity of 2.2 kilometers per second (Mach ~6.5) before separating and landing on a SpaceX drone ship.

Elon Musk’s SpaceX has signed its first ever deal with a major U.S. airline to provide wireless internet to passengers for free using the Starlink satellite network.

The deal with Hawaiian Airlines, which could be implemented as soon as next year, is expected to increase pressure on rival airlines to provide free Wi-Fi for passengers.

“Hawaiian doesn’t currently offer inflight Wi-Fi and has an extensive network of flights over the Pacific Ocean, serving the mainland U.S., Japan, Australia and New Zealand, among other destinations, from Hawaii,” CNBC reported. “It plans to offer Starlink connectivity on its flights out of its home state to cities throughout the mainland U.S. and to its international destinations.”

The official start of Atlantic Hurricane Season is less than six weeks away, and forecasters will be getting an essential upgrade just in time for the season to begin.

New technology from the University of Wisconsin will help with preparation of more detailed forecasts and provide more reliable information to meteorologists and emergency planners, which should ultimately result in better, safer outcomes for public safety.

The Advanced Dvorak Technique (ADT) is a satellite-based method for determining tropical cyclone intensity. Planned upgrades include the use of full-resolution images from weather satellites, better identification of the location of each storm’s eye and the ability to better analyze hurricanes occurring outside tropical regions.

NASA has picked SpaceX, Amazon and four other American companies to develop the next generation of near-Earth space communication services meant to support its future missions. The agency started looking for partners under the Communication Services Project (CSP) in mid-2021, explaining that the use of commercially provided SATCOM will reduce costs and allow it to focus its efforts on deep space exploration and science missions.

“Adopting commercial SATCOM capabilities will empower missions to leverage private sector investment that far exceeds what government can do,” NASA wrote in the official project page. By using technology developed by commercial companies, the agency will have continued access to any innovation they incorporate into the system. At the moment, NASA relies on its Tracking and Data Relay Satellite (TDRS) system for near-Earth space communications. Many of its satellites were launched in the 80’s and 90’s, though, and it’s set to be decommissioned in the coming years.

The funded agreements under NASA’s Communication Services Project has a combined value of $278.5 million, with SpaceX getting the highest cut. NASA expects the companies to match and exceed its contribution during the five-year development period. SpaceX, which proposed a “commercial optical low-Earth orbiting relay network for high-rate SATCOM services,” has been awarded $69.95 million. Amazon’s Project Kuiper is getting the second-highest cut and has been awarded $67 million, while Viasat Incorporated has been awarded $53.3 million. The other three awardees are Telesat US Services ($30.65 million), SES Government Solutions ($28.96 million) and Inmarsat Government Inc. ($28.6 million).

Circa 2021

As described above, molecular therapeutics enabling expression of a truncated dystrophin have been far developed. However, an unprecedented opportunity to correct the disease-causing mutation has arisen with the advent of Crispr-Cas9 technology (Fig. 1).

Since the generation of a Cas9-transgenic mouse [28], which allowed for pinpoint gene alterations specifically in organs targeted by AAVs encoding for the corresponding guide RNAs (gRNAs), it became clear that the inevitable course of inherited diseases might be altered by Cas9-mediated correction. Although certain limitations were unmasked early on, such as the preference of non-homologous end-joining (NHEJ) over homology-directed repair (HDR) upon enzymatic cleavage of the double stranded DNA by Cas9, or the packaging capacity of AAVs, muscular dystrophies seemed an ideal target for genome editing. DMD mutations inducing Duchenne muscular dystrophy (DMD) seemed particularly well suited, since internal truncations of the protein may lead to a shortened but stable protein with partial functional restitution and a milder disease progression, as seen in the allelic Becker muscular dystrophy (BMD).

Continue reading “Genome editing for Duchenne muscular dystrophy: a glimpse of the future?” »