Lifeboat Foundation

Nad plus works for alzheimers.

In June of 2,018 the World Health Organization (WHO) released the 11th edition of its International Classification of Diseases, and for the first time added aging.¹ The classification of aging as a disease paves the way for new research into novel therapeutics to delay or reverse age-related illnesses such as cancer, cardiovascular and metabolic disease, and neurodegeneration.^2,3 Nutrient sensing systems have been an intense focus of investigation, including mTOR (the mammalian target of rapamycin) for regulating protein synthesis and cell growth; AMPK (activated protein kinase) for sensing low energy states; and sirtuins, a family of seven proteins critical to DNA expression and aging, which can only function in conjunction with NAD+ (nicotinamide adenine dinucleotide), a coenzyme present in all living cells.⁴

Across the kingdom of life, an increase in intracellular levels of NAD+ triggers shifts that enhance survival, including boosting energy production and upregulating cellular repair.⁵ In fact, the slow, ineluctable process of aging has been described as a “cascade of robustness breakdown triggered by a decrease in systemic NAD+ biosynthesis and the resultant functional defects in susceptible organs and tissues.”⁶ Aging is marked by epigenetic shifts, genomic instability, altered nutrient sensing ability, telomere attrition, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and dysregulated intercellular communication.^7,8

By middle age, our NAD+ levels have plummeted to half that of our youth.⁹ Numerous studies have demonstrated that boosting NAD+ levels increases insulin sensitivity, reverses mitochondrial dysfunction, and extends lifespan.^10,11 NAD+ levels can be increased by activating enzymes that stimulate synthesis of NAD+, by inhibiting an enzyme (CD38) that degrades NAD+, and by supplementing with NAD precursors, including nicotinamide riboside(NR) and nicotinamide mononucleotide (NMN).^12,13 A conceptual framework called NAD World, formulated over the last decade by developmental biologist Shin-ichiro Imai, MD, PhD, of Washington University School of Medicine, posits NMN as a critical, systemic signaling molecule that maintains biological robustness of the communication network supporting NAD+.⁶.

A new book, published this week, explains where aging research is heading – and what you can do today to extend your healthspan. https://www.futuretimeline.net/.…/28-the-science-and…

Editorial reviews.

“A very compelling book.” —Ray Kurzweil, inventor and futurist.

Continue reading “The science and technology of growing young” »

A month after New Shepard’s first flight carrying people into space, a science flight without crew onboard has launched from Blue Origin’s facility near Van Horn, Texas. The flight, the fourth of the year for the New Shepard program, was originally scheduled for August 25 2021, but was delayed due to a payload integration issue.

New Shepard flight NS-17 lifted off on Thursday, August 26 at 09:31 CDT local time (14:31 UTC) — after two unplanned holds — on a suborbital trajectory with an apogee over 100 kilometers, the boundary to space as recognized by the Federation Aeronautique Internationale.

Continue reading “Blue Origin launches NS-17 suborbital science mission” »

Out today.

Sergey Young is a longevity investor and visionary with the XPRIZE his mission to extend healthy lifespans of at least one billion people. To do that, Sergey founded Longevity Vision Fund to accelerate life extension technological breakthroughs and to make longevity affordable and accessible to all.

Continue reading “How To Live To 150: The Science & Tech Of Growing Young | Lifespan.io Interview” »

The 23rd SpaceX

Commonly known as SpaceX, Space Exploration Technologies Corp. is a private American aerospace manufacturer and space transportation services company that was founded by Elon Musk in 2002. Headquartered in Hawthorne, California, the company designs, manufactures, and launches advanced rockets and spacecraft.

Expedition 65 Cool Science Radio Podcast — August 11 2021

Space station crew disusses life in space with cool science radio

Continue reading “Expedition 65 Cool Science Radio Podcast — August 11, 2021” »

Sun, Jul 11

This event is part of Summer Science 2021.

The ExoMars rover is due to launch in 2,022 and will travel across Oxia Planum on Mars drilling for signs of life.

Continue reading “Engineering ExoMars — Summer Science 2021” »

The Astronomy, Technology, and Space Science News Podcast.
SpaceTime Series 24 Episode 91
*Astronomers zero in on source of the impactor that wiped out the dinosaurs.
A new study claims the impactor believed to have wiped out and 75 percent of all life on Earth 66 million years ago including all the non-avian dinosaurs — likely came from the outer half of the main asteroid belt between Mars and Jupiter.
*Producing matter out of pure energy.
Scientists have directly converted pure light energy into matter in a single process for the first time.
The findings reported in the journal Physical Review Letters involved the creation of Electrons and their antimatter counter parts positrons — by colliding quantum packets of photons – light particles.
*Discovery of a galactic stream of galaxy clusters.
Astronomers have discovered a never-before-seen galaxy cluster with a black hole at its centre, travelling at high speed along an intergalactic road of matter.
*Solar Orbiter and BepiColombo making space history with double flyby of Venus.
As we go to air tonight the European Space Agency is making space history with two of its space craft6 undertaking almost simultaneous flybys of the planet Venus.
*The Science Report.
New US congressional report says COVID-19 leaked out of Chinese Government Wuhan Lab.
Wearing masks and social distancing even when vaccinated key to combat new COVID strains.
Rising sea levels may mean fewer eruptions from volcanic islands.
How slowing of the planet’s rotation could have paved the way for life on Earth.
Skeptic’s guide to low vaccination and low IQ.
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NASA’s Perseverance Mars rover recently attempted its first-ever sample collection of the Martian surface on August 6. However, data shows that while the rover’s drill successfully drilled into the surface, no regolith was collected in the sample tube.

Meanwhile, as Perseverance was preparing for the sample collection event, a team of researchers using ESA’s Mars Express orbiter found evidence that previously thought of lakes of water underneath Mars’ south pole might actually be made of clay.

Perseverance’s sample collection failure

Continue reading “Perseverance’s first sample collection fails, new science points to subsurface Martian clay lakes” »