Lifeboat Foundation

Last year, the Singularity Institute raised over $500,000. The World Transhumanist Association raised $50,000. The Lifeboat Foundation set a new record for the single largest donation. The Center for Responsible Nanotechnology’s finances are combined with those of World Care, a related organization, so the public can’t get precise figures. But overall, it’s safe to say, we’ve been doing fairly well. Most not-for-profit organizations aren’t funded adequately; it’s rare for charities, even internationally famous ones, to have a large full-time staff, a physical headquarters, etc.

The important question is, now that we’ve accumulated all of this money, what are we going to spend it on? It’s possible, theoretically, to put it all into Treasury bonds and forget about it for thirty years, but that would be an enormous waste of expected utility. In technology development, the earlier the money is spent (in general), the larger the effect will be. Spending $1M on a technology in the formative stages has a huge impact, probably doubling the overall budget or more. Spending $1M on a technology in the mature stages won’t even be noticed. We have plenty of case studies: Radios. TVs. Computers. Internet. Telephones. Cars. Startups.

The opposite danger is overfunding the project, commonly called “throwing money at the problem”. Hiring a lot of new people without thinking about how they will help is one common symptom. Having bloated layers of middle management is another. To an outside observer, it probably seems like we’re reaching this stage already. Hiring a Vice President In Charge Of Being In Charge doesn’t just waste money; it causes the entire organization to lose focus and distracts everyone from the ultimate goal.

I would suggest a top-down approach: start with the goal, figure out what you need, and get it. The opposite approach is to look for things that might be useful, get them, then see how you can complete a project with the stuff you’ve acquired. NASA is an interesting case study, as they followed the first strategy for a number of years, then switched to the second one.

Continue reading “Spending Effectively” »

The Defense Advanced Research Projects Agency (DARPA) gave a $540,000 grant to researchers from Rice University to do a fast-tracked 9-month study on a new anti-radiation drug based on carbon nanotubes:

“More than half of those who suffer acute radiation injury die within 30 days, not from the initial radioactive particles themselves but from the devastation they cause in the immune system, the gastrointestinal tract and other parts of the body,” said James Tour, Rice’s Chao Professor of Chemistry, director of Rice’s Carbon Nanotechnology Laboratory (CNL) and principal investigator on the grant. “Ideally, we’d like to develop a drug that can be administered within 12 hours of exposure and prevent deaths from what are currently fatal exposure doses of ionizing radiation.” […]

The new study was commissioned after preliminary tests found the drug was greater than 5,000 times more effective at reducing the effects of acute radiation injury than the most effective drugs currently available. […]

The drug is based on single-walled carbon nanotubes, hollow cylinders of pure carbon that are about as wide as a strand of DNA. To form NTH, Rice scientists coat nanotubes with two common food preservatives — the antioxidant compounds butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) — and derivatives of those compounds.

Continue reading “Promising Anti-Radiation Drug Based on Carbon Nanotubes” »

Cross posted from Next big future

Since a journal article was submitted to the Royal Society of Chemistry, the U of Alberta researchers have already made the processor and unit smaller and have brought the cost of building a portable unit for genetic testing down to about $100 Cdn. In addition, these systems are also portable and even faster (they take only minutes). Backhouse, Elliott and McMullin are now demonstrating prototypes of a USB key-like system that may ultimately be as inexpensive as standard USB memory keys that are in common use – only tens of dollars. It can help with pandemic control and detecting and control tainted water supplies.

This development fits in with my belief that there should be widespread inexpensive blood, biomarker and genetic tests to help catch disease early and to develop an understanding of biomarker changes to track disease and aging development. We can also create adaptive clinical trials to shorten the development and approval process for new medical procedures

The device is now much smaller than size of a shoe-box (USB stick size) with the optics and supporting electronics filling the space around the microchip

Continue reading “Cheap (tens of dollars) genetic lab on a chip systems could help with pandemic control” »

According to ScienceDaily:

The British-American biotech company Acambis reports the successful conclusion of Phase I trials of the universal flu vaccine in humans. The universal influenza vaccine has been pioneered by researchers from VIB and Ghent University. This vaccine is intended to provide protection against all ‘A’ strains of the virus that causes human influenza, including pandemic strains. Therefore, this vaccine will not need to be renewed annually.

What would make this new vaccine different from the ones already available is that it would target M2e, a conserved region of influenza “A” strains. Since that part doesn’t constantly mutate and about 2/3 of seasonal epidemics and all pandemics are due to type “A” strains, it could be a very efficient weapon against repeats of the “Spanish Flu” (1918−1919) that killed at least 50 million people worldwide. Only the future will tell if phase II and III trials are successful.

You can learn more about the Lifeboat Foundation BioShield program here.

Reposted from Next Big Future which was advancednano.

A 582,970 base pair sequence of DNA has been synthesized.

It’s the first time a genome the size of a bacterium has chemically been synthesized that’s about 20 times longer than [any DNA molecule] synthesized before.

This is a huge increase in capability. It has broad implications for DNA nanotechnology and synthetic biology.

Continue reading “On the brink of Synthetic Life: DNA synthesis has increased twenty times to full bacteria size” »

On January 29th, 2008, Near Earth Object 2007 TU24 will intersect Earth’s orbit at the startling proximity of only 0.0038AU — or 1.4 lunar distances from our planet. According to the resources I reviewed, this NEO represents the closest known approach to Earth until 2027, assuming no more surprises like the 2007 TU24, which was discovered on October 11th, 2007.

That an asteroid won’t strike is an assumption we can’t afford to make. 2007 TU24 will not impact the planet but may pass through a portion of Earth’s magnetosphere. We can’t predict the repercussions of this transit with any certainty at this time. However, the possibilities range from no effect to potentially catastrophic changes to weather, tectonic plate movement, the oceans, and more.

Some might say that we do not need to be concerned — that this kind of near miss (and let’s be frank here — in the vastness of even our solar system, 1.4 lunar distances from Earth is a near miss) is a freak occurrence. Don’t be so sure. One day later — that’s right, on January 30th, it was thought possible — one might even say reasonably likely — that another asteroid would strike our second nearest celestial neighbor, Mars.

Continue reading “Is 2007 TU24 A Wake Up Call?” »

PhysOrg.com is reporting that researchers at Purdue University are working to develop a system that would use a network of cell phones to track radiation in an effort to prevent terrorist attacks with dirty bombs or nuclear weapons. Tiny solid-state radiation sensors are already commercially available and the additional circuitry would not add significant bulk to portable electronic products.

The researchers tested the system and demonstrated that it is capable of detecting a weak radiation source 15 feet from the sensors. A fully developed system could cover a nation with millions of cell phones equipped with radiation sensors able to detect even light residues of radioactive material. Because cell phones already contain global positioning locators, the network of phones would serve as a large scale tracking system that would require no intervention from individual users.

In his most recent paper “Reducing the Risk of Human Extinction,” SAB member Jason G. Matheny approached the topic of human extinction from what is unfortunately a somewhat unusual angle. Jason examined the cost effectiveness of preventing humanity’s extinction due to a catastrophic asteroid impact.

Even with some rather pessimistic assumptions, his calculations showed a pretty convincing return on investment. For only about US$ 2.50 per life year saved, Matheny predicts that we could mitigate the risk of humanity being killed off by a large asteroid. Maybe it’s just me, but it sounds pretty compelling.

Matheny also made a very good point that we all should ponder when we consider how our charitable giving and taxes gets spent. “We take extraordinary measures to protect some endangered species from extinction. It might be reasonable to take extraordinary measures to protect humanity from the same.”

For more coverage on this important paper please see the October 2007 issue of Risk Analysis and a recent edition of Nature News.

Newsweek is reporting the results of a scientific study by researchers at Carnegie Mellon who used MRI technology to scan the brains of human subjects. The subjects were shown a series of images of various tools (hammer, drill, pliers, etc). The subjects were then asked to think about the properties of the tools and the computer was tasked with determining which item the subject was thinking about. To make the computer task even more challenging, the researchers excluded information from the brain’s visual cortex which would have made the problem a simpler pattern recognition exercise in which decoding techniques are already known. Instead, they focused the scanning on higher level cognitive areas.

The computer was able to determine with 78 percent accuracy when a subject was thinking about a hammer, say, instead of a pair of pliers. With one particular subject, the accuracy reached 94 percent.