Menu

Blog

Page 194

Sep 23, 2024

Groundbreaking Study Unveils Novel Treatment for Blocking SARS-CoV-2 Entry into Cells

Posted by in categories: bioengineering, biotech/medical, chemistry, economics, health

The SARS-CoV-2 pandemic has had an unprecedented impact on global public health and the economy. Although vaccines and antivirals have provided effective protection and treatment, the development of new small molecule-based antiviral candidates is imperative to improve clinical outcomes against SARS-CoV-2. In this study, we identified UNI418, a dual PIKfyve and PIP5K1C inhibitor, as a new chemical agent that inhibits SARS-CoV-2 entry into host cells. UNI418 inhibited the proteolytic activation of cathepsins, which is regulated by PIKfyve, resulting in the inhibition of cathepsin L-dependent proteolytic cleavage of the SARS-CoV-2 spike protein into its mature form, a critical step for viral endosomal escape. We also demonstrated that UNI418 prevented ACE2-mediated endocytosis of the virus via PIP5K1C inhibition. Our results identified PIKfyve and PIP5K1C as potential antiviral targets and UNI418 as a putative therapeutic compound against SARS-CoV-2.

Despite the ongoing threat posed by new viruses following the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which led to the coronavirus disease 2019 (COVID-19) pandemic, new antiviral drugs continue to be developed to effectively block viral entry into the human body.

Professor Kyungjae Myung and his research team in the Department of Biomedical Engineering, affiliated with the IBS Center for Genomic Integrity, has discovered UNI418, a compound that effectively prevents the penetration of the coronavirus. This compound works by regulating dielectric homeostasis, thereby inhibiting the virus’s entry into human cells.

Sep 23, 2024

E5 treatment showing improved health‐span and lifespan in old Sprague Dawley rats

Posted by in categories: biotech/medical, chemistry, life extension

In the present investigation, the SD rats were separated into two groups old control group and the treatment group (n = 8). The treatment group received four injections of E5 every alternate day for 8 days, and eight injections every alternate day for 16 days. Body weight, grip strength, cytokines, and biochemical markers were measured for more than 400 days of the study. Clinical observation, necropsy, and histology were performed. The E5 treatment exhibited great potential by showing significantly improved grip strength, remarkably decreased pro-inflammatory markers of chronic inflammation and oxidative stress, as well as biomarkers for vital organs (BUN, SGPT, SGOT, and triglycerides), and increased anti-oxidant levels. Clinical examinations, necropsies, and histopathology revealed that the animals treated with the E5 had normal cellular structure and architecture. In conclusion, this unique ‘plasma-derived exosome’ treatment (E5) alone is adequate to improve the health-span and extend the lifespan of the old SD rats significantly.

Sep 23, 2024

New results from the CMS experiment put W boson mass mystery to rest

Posted by in category: particle physics

After an unexpected measurement by the Collider Detector at Fermilab (CDF) experiment in 2022, physicists on the Compact Muon Solenoid experiment (CMS) at the Large Hadron Collider (LHC) announced today a new mass measurement of the W boson, one of nature’s force-carrying particles.

Sep 23, 2024

New measurement of the top quark from LHC data

Posted by in category: particle physics

Researchers from the School of Physics & Astronomy have been involved in an important new measurement of the top quark made using data provided by the Large Hadron Collider (LHC).

Sep 23, 2024

[Part 1] Inside the Loop: Decoding the Mystery of Self-Awareness in Cognitive Systems

Posted by in category: neuroscience

“The only journey is the one within”

Rainer Maria Rilke

Feedback loops within a system can generate seemingly contradictory or paradoxical relationships. A cognitive system might have an internal model of its mental processes, which influences its decision-making and behavior. This internal model then becomes part of the system’s overall state, creating a recursive loop where the system’s representation of itself affects its own behavior.

Sep 22, 2024

Primordial Dark Energy: Solving Astronomy’s Biggest Mysteries

Posted by in category: cosmology

Discover how primordial dark energy could unravel astronomy’s greatest puzzles—from the Hubble tension to early galaxy formation—with FreeAstroScience.

Sep 22, 2024

Reversing the aging clock: A tiny plant protein holds the secret

Posted by in categories: futurism, life extension

Scientists may have unlocked anti-aging secrets by studying a plant cell organelle:


Research team stumble upon new discovery which potentially holds the key to aging in plants. Click here to find out what this means for the future.

Sep 22, 2024

EA Looking to Use AI to Take User-Generated Content to the Next Level

Posted by in category: robotics/AI

I expect this around 2029/2030, so about 5-ish years. Phase 1 of it will be: hey Ai, i didnt really like that level, mission, story line, etc… edits on the fly. Phase 2 of it will be creating DLC on the fly. And, Phase 3 will be just telling an AI roughly what you want to play, and it tries to build it.


Publishing giant Electronic Arts shows a concept of the different ways users could generate their own content in a game using generative AI.

Sep 22, 2024

A 150-Year Flight to a New Earth | Sci-Fi Documentary 4K | ReYOUniverse

Posted by in categories: cosmology, education, media & arts

Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.

Sep 22, 2024

MIT engineers’ revolutionize the design and operation of wind farms

Posted by in category: sustainability

Engineers have long known that traditional aerodynamics models, used to design the blades of wind turbines and propellers, don’t account for certain real-world conditions. Though these formulas, established over a century ago, work well in basic scenarios, they falter when applied to high forces, extreme speeds, or complex angles. This has led engi…

Page 194 of 11,946First191192193194195196197198Last