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“Machine-Learning Assisted Directed Evolution of Viral Vectors and Microbial Opsins for Minimally Invasive Neuroscience.” AI-4-Science Workshop, October 25, 2019 at Bechtel Residence Dining Hall, Caltech. Learn more about: — AI-4-science: https://www.ist.caltech.edu/ai4science/ — Events: https://www.ist.caltech.edu/events/ Produced in association with Caltech Academic Media Technologies. ©2019 California Institute of Technology.

Gravity measurement benefits from optical lattice.

The European Space Agency’s member countries have endured a space access predicament as they have waited to have a functioning rocket in their toolbox.

But a new rocket, dubbed Ariane 6, just launched on its maiden mission after years of delays and hang-ups in the development process.

If successful, the space agency hopes that the Ariane 6 rocket system may go on to make the space agency more self-reliant and perhaps challenge SpaceX’s dominance in the global market for launching satellites.

Summary: Researchers have discovered how glial cells can be reprogrammed into neurons through epigenetic modifications, offering hope for treating neurological disorders. This reprogramming involves complex molecular mechanisms, including the transcription factor Neurogenin2 and the newly identified protein YingYang1, which opens chromatin for reprogramming.

The study reveals how coordinated epigenome changes drive this process, potentially leading to new therapies for brain injury and neurodegenerative diseases.

“My work shows that we need to look more carefully at how ocean biology can affect the climate,” said Dr. Jonathan Lauderdale.

How will climate change influence the ocean’s circulation in the future? This is what a recent study published in Nature Communications hopes to address as a researcher from Massachusetts Institute of Technology (MIT) investigated how could hinder the ocean’s mechanisms of transferring carbon between the ocean floor and the planet’s atmosphere. This study holds the potential to help researchers, climate scientists, and the public better understand the long-term impacts of climate change and what steps that can be taken to mitigate them.

For the study, Dr. Jonathan Lauderdale, who is a Research Scientist in the Program in Atmospheres, Oceans, and Climate (PAOC) at MIT used models to challenge previous studies pertaining to the transfer of nutrients, specifically carbon, between the ocean floor and the Earth’s atmosphere, with an emphasis on a specific class of molecules called “ligands”. These previous studies dating back 40 years have hypothesized that weaker ocean circulation results in reduced levels of carbon dioxide being transferred to the atmosphere.

Continue reading “Predicted Weakening of Ocean’s Overturning Circulation” »

According to a new study of rivers and lakes in Wisconsin, natural foams from these bodies of water contain much higher concentrations of per-and polyfluoroalkyl substances (PFAS) than the water below them.

Thirty-six different kinds of PFAS compounds were analyzed in samples of both the foams and water surface microlayers of 43 Wisconsin rivers and lakes. The study, which is published in Environmental Science & Technology, also revealed that foams, generally off-white and found along shorelines, are not necessarily an indicator of elevated contamination levels in the entire water body.

“We studied many different lakes and found PFAS in all of them. The PFAS concentrations were high in the foams even if the concentrations in the water were relatively low,” said Christy Remucal, a professor with the University of Wisconsin–Madison Department of Civil and Environmental Engineering and interim director of the University of Wisconsin Aquatic Sciences Center.

For decades now, scientists have argued about how the universe is shaped, in the sense of complex parameters that govern the rules of space and time. Is it a simple open expanse, like a bigger version of the spaces we’re used to? Does it wrap around on itself like a donut? Or something even stranger?

Now, new research published in the journal Physical Review Letters, in the inaugural paper from a new consortium of cosmologists known as the COMPACT Collaboration, found that the “topology” of the universe — the shape of its geometry, basically — is likely anything but simple.

The researchers looked at the universe’s cosmic microwave background, which is basically the inherent “glow” of space, dating back to ancient radiation at the dawn of time.

Researchers have significantly improved gene-editing techniques. This new method, called eePASSIGE, can insert or replace entire genes in human cells with much higher efficiency than previous methods. This advancement could lead to a single gene therapy for diseases caused by various mutations in a single gene, like cystic fibrosis. Traditionally, gene therapy required a different treatment for each mutation.

EePASSIGE combines prime editing, which edits small stretches of DNA, with new enzymes that insert large pieces of DNA. This allows scientists to introduce a healthy copy of a gene directly where it belongs in the genome.

“This is one of the first examples of targeted gene integration with potential for therapeutic applications,” said Dr. David Liu, senior author of the study. “If these efficiencies translate to patients, many genetic diseases could be treated.”

Microbes that are used for health, agricultural, or other applications need to be able to withstand extreme conditions, and ideally the manufacturing processes used to make tablets for long-term storage. MIT researchers have now developed a new way to make microbes hardy enough to withstand these extreme conditions.

Their method involves mixing bacteria with food and drug additives from a list of compounds that the FDA classifies as “generally regarded as safe.” The researchers identified formulations that help to stabilize several different types of microbes, including yeast and bacteria, and they showed that these formulations could withstand high temperatures, radiation, and industrial processing that can damage unprotected microbes.