Lifeboat Foundation

DNA repair and DNA damage signaling pathways are critical for the maintenance of genomic stability.

In this review, Hopkins et al. review the major classes of DNA repair and damage signaling defects in cancer, the genomic instability that they give rise to, and therapeutic strategies to exploit the resulting vulnerabilities. They also discuss the impacts of DNA repair defects on both targeted therapy and immunotherapy, and highlight emerging principles for targeting DNA repair defects in cancer therapy.

This lifeform can cheat time. Could it also help us push the boundaries of biology?

“Solar system formation models using the new solar composition successfully reproduce the compositions of large Kuiper Belt objects (KBOs) and carbonaceous chondrite meteorites, in light of the newly returned Ryugu and Bennu asteroid samples from JAXA’s Hayabusa-2 and NASA’s OSIRIS-REx missions.”

To make this discovery, the team combined new measurements of solar neutrinos and data about the solar wind composition from NASA’s Genesis mission, together with the abundance of water found in primitive meteorites that originated in the outer solar system. They also used the densities of large KBOs such as Pluto and its moon Charon, as determined by NASA’s New Horizons mission.

“This work provides testable predictions for future helioseismology, solar neutrino and cosmochemical measurements, including future comet sample return missions,” Truong said.

Intel is planning to launch its next-gen Arc Battlemage desktop GPUs next month, competing in the mid-range segment against Intel & AMD.

Intel Expected To Reveal Decisive Information Around Arc Battlemage “Desktop” GPUs Next Month, Setting The Tone For Next-Gen GPU Markets

Although Intel’s first-gen Arc Desktop GPUs saw little success in the gaming segment, the next-gen is now planned for an unveiling next month.

Aiming to rival global tech hubs, Saudi Arabia’s new AI project targets innovation, infrastructure, and talent development.

A research team from the University of Basel has succeeded in synthesizing simple, environmentally sensitive cells complete with artificial organelles. For the first time, the researchers have also been able to emulate natural cell-cell communication using these protocells—based on the model of photoreceptors in the eye. This opens up new possibilities for basic research and applications in medicine.

Researchers at the University of São Paulo (USP) in Brazil have developed a novel nanotechnology-based solution for the removal of micro-and nanoplastics from water. Their research is published in the journal Micron.

After 20 years, the biggest experiment in history is ready: This is what it will show. It is called the ALICE experiment which is set to operate soon.

For example, enhancers (DNA segments that promote gene expression) and gene promoters (regions that initiate transcription) can interact more readily in open, accessible regions of chromatin.

On the other hand, DNA in tightly packed chromatin regions remains less active. Through analyzing these contact points, researchers have developed models to map chromatin configurations across various species, such as humans, mice, birds, and more recently, turtles.

In a recent paper published in the journal Genome Research, Valenzuela’s team described the chromatin arrangement in the genomes of two turtle species, the spiny softshell and northern giant musk turtles, uncovering a structure previously unobserved in other organisms.