Lifeboat Foundation

Today, we will be taking a look at a new study showing that an NAD+ precursor was able to improve mitochondrial function in cells and flies with a model of Parkinson’s disease.

Summary

While mitochondrial dysfunction is emerging as key in Parkinson’s disease (PD), a central question remains whether mitochondria are actual disease drivers and whether boosting mitochondrial biogenesis and function ameliorates pathology. We address these questions using patient-derived induced pluripotent stem cells and Drosophila models of GBA-related PD (GBA-PD), the most common PD genetic risk. Patient neurons display stress responses, mitochondrial demise, and changes in NAD+ metabolism. NAD+ precursors have been proposed to ameliorate agerelated metabolic decline and disease. We report that increasing NAD+ via the NAD+ precursor nicotinamide riboside (NR) significantly ameliorates mitochondrial function in patient neurons. Human neurons require nicotinamide phosphoribosyltransferase (NAMPT) to maintain the NAD+ pool and utilize NRK1 to synthesize NAD+ from NAD+ precursors. Remarkably, NR prevents the age-related dopaminergic neuronal loss and motor decline in fly models of GBA-PD.

Continue reading “NAD+ Precursor Has Therapeutic Potential Against Parkinsons Disease” »

Researchers at the University of California San Diego School of Medicine have shown that they can block inflammation in mice, thereby protecting them from liver disease and hardening of the arteries while increasing their healthy lifespan.

The study, published in the journal Nature, shows that inflammation can be blocked using a naturally occurring antibody that binds with oxidized phospholipids (OxPL), molecules that are located on the cell surface and are modified by inflammation [1]. This is the first time in a living animal that OxPL has been shown to trigger inflammation that leads to the formation of arterial plaques, the foundation of heart disease.

The mice were given a high-fat diet and treated with the antibody, which prevented artery-hardening arterial plaques from forming, prevented liver disease, and increased their lifespan. The study results also highlight a potential new approach to preventing or reversing a variety of inflammatory diseases.

Continue reading “Using a Natural Antibody to Combat Atherosclerosis” »

CFTC head to the UN: Cryptocoins aren’t going anywhere; “we are witnessing a technological revolution”

Introduction

Good evening. The United Nations has played a special role in my life. I grew up close by, about 20 miles away in northern New Jersey. More importantly, my Aunt is the founder and president of the International Health Awareness Network (IHAN), which works in consultative status with the Department of Public Information of the United Nations. Consequently, from the first days of that ambitious project back in 1987, she was often in these buildings advocating her vision, and seeking support for the organization, which aspires to “educate, empower and provide health care to socioeconomically underserved women and children.” My family would come to see her here. And occasionally, I had the great fortune of participating at IHAN events, listening to the speeches, and hearing about the organization’s vision to fulfill its mission. Those moments are themselves transformational, and foundational in setting my agenda for facilitating change in the future.

Additionally, in 2008, my sister’s wedding reception was held in the Delegates Dining Room of the United Nations. A spectacular night for my family, and another reason why this building and institution is so special to me.

Astronaut is life.

A relatively inexperienced crew of two astronauts and a cosmonaut blasted off Wednesday from the Baikonur cosmodrome in Kazakhstan for a five-month mission on the International Space Station.

Scientists can 3D-print a human cornea in ten minutes.

I, for one, still dream of flourishing in the future through advances in science and technology, but hopefully one that addresses societal inequities, retains the richness and diversity of our natural systems and indigenous cultures, rather than the somewhat simple and sterile futures depicted by many science fiction writers and futurists. Timothy Leary liked to remind us to remember our hippie roots, with their celebration of diversity and nature, and I hear him calling us again.

What used to be the province of acid-tripping tie-dye wearers has been co-opted by Silicon Valley—and we must be responsible about how we wield this new reality.

E xperts are suggesting quantum computing may render blockchain obsolete. As the tech giants such as Google and IBM are showing interest in Quantum computing the danger is evident. According to MIT Technology Review, this type of computing can hack the cryptography hash that universally secures the blockchain and in general the internet. This would suggest quantum computers may complete fraudulent transactions and steal coins. With its exponential power, quantum computers threaten blockchain’s future security.

Blockchain consists of encrypted nodes connected on a chain, which currently makes it almost impossible to hack. The order of entries adheres to the blockchain protocol, which makes it counterfeit-resistant.

To successfully hack a blockchain, you would need to alter both the targeted block and all of the blocks connected. Blockchains are synced throughout a peer-to-peer network. In this type of system, there is no central point of failure for hackers to penetrate. For a hacker to have a chance of penetrating the network, they would need to simultaneously alter at least 51% of the blockchain.

Continue reading “Quantum Computing: Is it the end of blockchain?” »

By Andy Coghlan

Many people with cancer die not from their original tumour, but from secondary tumours that grow elsewhere around the body. Now we’re a step closer to understanding how cancers are able to spread.

Sakari Vanharanta of the Medical Research Council Cancer Unit at the University of Cambridge and his colleagues have been studying kidney cancer cells. They found that to spread, these cells tap into the same genetic “travel” machinery normally used by healthy white blood cells to roam around the body.

Continue reading “Kidney cancer spreads” »

AMD at Computex 2018 unveiled what may turn out to be one of the most exciting GPU designs in town, the world’s first 7nm GPU, which packs as much as 32GB of high-bandwidth memory.

However, that product won’t really be available for purchase anytime soon, unless you’re in the business of developing machine learning (ML) and artificial intelligence (AI) products.

Don’t Miss : Amazon’s offering a rare discount on the adapter that speeds up your Fire TV Stick or 4K Fire TV.

Continue reading “AMD just unveiled the world’s most exciting GPU, but you’re not going to be playing ‘Fortnite’ on it” »