Lifeboat Foundation

DALLAS – March 29, 2018 – Researchers from UT Southwestern’s Charles and Jane Pak Center for Mineral Metabolism and Clinical Research and Internal Medicine’s Division of Nephrology recently published work in Nature that reveals the molecular structure of the so-called “anti-aging” protein alpha Klotho (a-Klotho) and how it transmits a hormonal signal that controls a variety of biologic processes. The investigation was performed in collaboration with scientists from New York University School of Medicine and Wenzhou Medical University in China.

Studies at UTSW two decades ago by Dr. Makoto Kuro-o, Professor of Pathology, demonstrated that mice lacking either a-Klotho or the hormone FGF23 suffered from premature and multiple organ failure as well as other conditions, including early onset cardiovascular disease, cancer, and cognitive decline. Because defects in a-Klotho lead to symptoms seen in aging, researchers inferred that a-Klotho suppresses aging, leading to great interest in how the a-Klotho protein might work together with the hormone FGF23 to fulfill their roles.

A-Klotho can exist on the surface of a cell or can be released from the cell and circulate in body fluids, including the blood, as soluble a-Klotho. The cell-attached form and the circulating form of a-Klotho were previously and universally believed to serve completely different functions.

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How SETI sifts through cosmic noise to hunt for alien signals.

Follow Focal Point for more stories on groundbreaking science!

Google and Amazon are on the forefront of AI innovation. But have they already gone too far?

By John Brandon Contributing editor, Inc.com

WASHINGTON — The U.S. military got is first big taste of artificial intelligence with Project Maven. An Air Force initiative, it began more than a year ago as an experiment using machine learning algorithms developed by Google to analyze full-motion video surveillance.

The project has received high praise within military circles for giving operators in the field instant access to the type of intelligence that typically would have taken a long time for geospatial data analysts to produce.

Project Maven has whetted the military’s appetite for artificial intelligence tools. And this is creating pressure on the National Geospatial-Intelligence Agency to jump on the AI bandwagon and start delivering Maven-like products and services.

Continue reading “Artificial intelligence is changing everything, ‘We need a different mentality’” »

This image shows the bright light of a solar flare on the left side of the Sun and an eruption of solar material shooting through the Sun’s atmosphere.

Two new studies analyzing the relationship between dark energy, life, and the multiverse suggest it’s possible life exists in universes outside our own. Though the idea of the multiverse is not new, the concept of our universe being extraordinarily special might not be true.

While you can’t teach an old dog new tricks, you may be able to make your pup young again.

A Harvard startup has begun preliminary experiments on beagles and claims it can make animals ‘younger’ by adding new DNA instructions to their bodies.

Continue reading “Startup that wants you to ‘live to 130 in the body of a 22-year-old’” »

And inflammation is one of the three primary ageing processes.

Scientists have discovered a new metabolic process in the body that can switch off inflammation. They have discovered that ‘itaconate’—a molecule derived from glucose—acts as a powerful off-switch for macrophages, which are the cells in the immune system that lie at the heart of many inflammatory diseases including arthritis, inflammatory bowel disease and heart disease.

The scientists, working in the School of Biochemistry and Immunology in the Trinity Biomedical Sciences Institute at Trinity College Dublin, hope their discovery will have relevance for inflammatory and infectious diseases—and that their findings may also help to develop much-needed new drugs to treat people living with these conditions.

Professor of Biochemistry at Trinity, Luke O’Neill, was, along with Dr. Mike Murphy of the University of Cambridge, the joint leader of the work just published in leading international journal Nature. The discoveries were made using both human cells and mice as a model organism.

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Hats off to scientists that keep finding novel methods to fight cancer.

The ever increasing research in cancer cure has led to the market growth of a popular new solution — Antibody-drug conjugates.