Lifeboat Foundation

You can’t peer very far down into a well or below the surface of the ocean before things go dark—light does not penetrate to such depths. Though the brain is far from bottomless, neuroscientists face the same lack of light when they try to study living deep-brain structures. This is especially frustrating given that optogenetics, a method for manipulating genetically tagged brain cells with light, has exploded in popularity over the past decade. “Optogenetics has been a revolutionary tool for controlling neurons in the lab, and hopefully someday in the clinic,” says Thomas McHugh, research group leader at the RIKEN Brain Science Institute in Japan. “Unfortunately, delivering light within brain tissue requires invasive optical fibers.”

McHugh and colleagues now have a solution for sending light to new depths in the brain. As they report in Science on February 9, upconversion nanoparticles (UCNPs) can act as a conduit for laser light delivered from outside the skull. These nanoparticles absorb near-infrared laser light and in turn emit visible photons to areas that are inaccessible to standard optogenetics. This method was used to turn on neurons in various brain areas as well as silence seizure activity and evoke memory cells. “Nanoparticles effectively extend the reach of our lasers, enabling the ‘remote’ delivery of light and potentially leading to non-invasive therapies,” says McHugh.

In optogenetics, blue-green light is used to turn neurons on or off via light-responsive ion channels. Light at these wavelengths, however, scatters strongly and is at the other end of the spectrum from the near-infrared light that can penetrate deeper into brain tissue. UCNPs composed of elements from the lanthanide family can act as a bridge. Their ‘optogenetic actuation’ turns low-energy near-infrared laser light into blue or green wavelengths for control of specifically labeled cells. Though such bursts of light deliver considerable energy to a small area, temperature increases or cellular damage were not observed.

Continue reading “Nanoparticles Enable Non-Invasive Optogenetic Control of Brain Cell Activity With Near-Infrared Light” »

No cameras needed to keep an eye on your home.

The Tesla Roadster and its mannequin driver that launched into space aboard SpaceX’s first Falcon Heavy rocket on Tuesday (Feb. 6), has been spotted by a telescope on the ground.

What if I told you that we could regenerate our teeth? Well, that may soon be a possibility thanks to new research showing that teeth can be encouraged to regrow. Rather than drilling holes into teeth and plugging them with artificial fillers, dentists in the near future may be able to rebuild your teeth with a new technique.

Stimulating stem cells

Professor Paul Sharpe, a scientist based at King’s College in London, and his team have found a way to do just this in mice. They published a study last year that described this new approach[1].

Major psychiatric disorders like autism, schizophrenia and bipolar appear to have more in common than we thought they did. A new study finds that they have important similarities at a molecular level.

And understanding the molecular basis of major disorders such as autism, schizophrenia and bipolar is hopeful, because it could help in developing better treatments for them.

These psychiatric disorders are diagnosed by how a patient behaves. There are no clear signs on a brain “that you can see with your eyes or most microscopic techniques,” says Dan Geschwind, a professor of neurogenetics at UCLA. His team’s findings were published in Science this week.

Continue reading “Major Psychiatric Disorders Have More In Common Than We Thought, Study Finds” »

The feat could lead to new ways of preserving women’s fertility.

The photos broke the record of the famous 1990 photo of the “Pale Blue Dot.”

If humans are destined for deep space, they need to understand the space environment changes health, including aging and antibiotic resistance.

A new NASA project could help. It aims to develop technology used to study “omics”—fields of microbiology that are important to human health. Omics includes research into genomes, microbiomes and proteomes.

The Omics in Space project is being led by NASA’s Jet Propulsion Laboratory in Pasadena, California. The project was recently funded by NASA’s Translational Research Institute for Space Health four years of study. Over that time, NASA hopes to develop 3D printable designs for instruments on the International Space Station (ISS), that can handle liquids like blood samples without spilling in microgravity. These tools could enable astronauts to analyze biological samples without sending them back to Earth.

The gallium-nitride HEMT-LED lets voltage control light, replacing typical LED support circuitry.