Researchers at the University of Alabama at Birmingham have discovered a potential target for therapies that may prevent or delay heart failure from pressure overload of the heart. It could also be a biomarker to warn physicians that a patient is at risk of this happening.
Early macrophage infiltration is a step in heart failure
In a new study, Dr. Sumanth Prabhu and his team showed that preventing the early infiltration of CCR2+ macrophages into the heart, in a mouse model of heart failure, significantly reduced enlargement of the heart and the decline of the pumping ability that leads to heart failure [1]. This means that the infiltration of macrophages is a critical step in heart failure.
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