The compounds — AP39, AP123 and RT01 — have been designed to selectively deliver minute quantities of the gas hydrogen sulphide to the mitochondria in cells and help the old or damaged cells to generate the ‘energy’ needed for survival and to reduce senescence.
In the samples used, the number of senescent cells — older cells that have deteriorated and stopped dividing — was reduced by up to 50 per cent.
The team also identified two splicing factors — a component of cells — that play a key role in when and how endothelial cells become senescent.
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