Lifeboat Foundation

When the gene-editing technology CRISPR first made a splash back in 2012, it foretold a future in which curing diseases might simply involve snipping out problematic bits of genetic code. Of course, innovation is rarely so straightforward. As incredible as CRISPR is, it also has some pretty sizable flaws to overcome before it can live up to its hype as a veritable cure-all for human disease.

A new study published this week in the journal Nature Genetics tackles one CRISPR complication. CRISPR gene-editing systems can easily cut many pieces of DNA at once, but actually editing all those genes is a lot more time-consuming. Now, scientists at UCLA have come up with a way to edit multiple genes at once.

When scientists use CRISPR for genetic engineering, they are really using a system made up of several parts. CRISPR is a tool taken from bacterial immune systems. When a virus invades, the bacterial immune system sends an enzyme like Cas9 to the virus and chops it up. The bacteria then adds short bits of virus DNA to its own code, so it can recognize that virus quickly in the future. If the virus shows up again, a guide RNA will lead the Cas9 enzyme to the matching place in the virus code, where it again chops it up. In CRISPR, when that cutting is done, scientists can also insert a new bit of code or delete code, to, for example, fix disease-causing genetic mutations in the code before patching it up. But delivering that new code and making the patch is where it can get especially tricky.

Continue reading “Scientists Edit Thousands of Genes at Once With Upgraded CRISPR” »

Glow-in-the-dark tumors for cancer detection, and cryopreservation of organs are among the seven breakthrough technologies researchers announce.

Glow-in-the-dark cancer tumors, cryopreservation of organs and a vaccine patch are among the seven breakthrough medical technologies announced by researchers in a March 2018 release. [This article first appeared on LongevityFacts. Author: Brady Hartman. ]

Glow-in-the-dark cancer tumors, alcohol tattoos, MRI coils, a malaria pill, tracers that light up prostate cancer, cryopreservation of organs and a needle-free vaccine patch are breakthrough medical technologies sponsored by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) and showcased in March of 2018.

Continue reading “7 Revolutionary Medical Technologies” »

Hedrick’s close call inspired his research team to design a new molecule, called a polymer, that targets five deadly types of drug-resistant microbes and kills them like ninja assassins. Their research, a collaboration with Singapore’s Institute of Bioengineering and Nanotechnology, was reported recently in the journal Nature Communications.

If commercialized, the polymer could boost the fight against “superbugs” that can fend off every antibiotic that doctors throw at them. An estimated 700,000 people worldwide die every year from these untreatable infections.

In 2017, synthetic biology companies raised a record amount of funding – just over $1.8 billion for fifty two companies – driven mostly by several multi-hundred million dollar deals. This was a 50% increase over the previous year, a pace of growth that indicated an intense interest in the field from outside investors. It seems that this interest has only intensified since then, as 27 companies raised $650 million in funding during the first quarter of 2018, which is double the activity of the first quarter of 2017. At this rate, the field is on track to raise over $2.4 billion with over 100 companies being funded, which would be a record for both statistics.

The companies raising money in 2018 are pursuing a broadly diverse set of applications from all sections of the synthetic biology technology stack. Many companies are developing products that will eventually end up in the hands (or bodies) of everyday consumers, but others are making the tools and reagents that will empower the whole field to become more productive. It is important that all of these types of companies exist in order to build a healthy industry ecosystem.

Continue reading “Synthetic biology companies raised over $650 million in Q1, setting the pace for another record-breaking year” »

Advocates of transhumanism face a similar choice today. One option is to take advantage of the advances in nanotechnologies, genetic engineering and other medical sciences to enhance the biological and mental functioning of human beings (never to go back). The other is to legislate to prevent these artificial changes from becoming an entrenched part of humanity, with all the implied coercive bio-medicine that would entail for the species.

We can either take advantage of advances in technology to enhance human beings (never to go back), or we can legislate to prevent this from happening.

Continue reading “Transhumanism: advances in technology could already put evolution into hyperdrive – but should they?” »

A new study has posited the idea that microbial life could exist in Venus’s clouds.

In a new study, scientists are exploring the idea that life could be lurking high up in the clouds of Venus, and suggest that the planet’s atmosphere would be the perfect place to begin a search for microbial life.

Scientist Sanjay Limaye, who works at the University of Wisconsin–Madison’s Space Science and Engineering Center, conducted the latest research with a group of international researchers and noted that it is highly possible that Venus may have once had a plentiful supply of liquid water on the planet’s surface that could have been in existence for at least 2 billion years, according to Phys. Org.

Continue reading “Scientists Explore The Possibility Of Life Hidden Inside The Clouds Of Venus” »

Flaws in a study about unintended gene editing snips have led to its retraction. But that’s not the end of the story.

Scientists are increasingly betting their time and effort that the way to control the world is through proteins. Proteins are what makes life animated. They take information encoded in DNA and turn it into intricate three-dimensional structures, many of which act as tiny machines. Proteins work to ferry oxygen through the bloodstream, extract energy from food, fire neurons, and attack invaders. One can think of DNA as working in the service of the proteins, carrying the information on how, when and in what quantities to make them.

Living things make thousands of different proteins, but soon there could be many more, as scientists are starting to learn to design new ones from scratch with specific purposes in mind. Some are looking to design new proteins for drugs and vaccines, while others are seeking cleaner catalysts for the chemical industry and new materials.

David Baker, director for the Institute for Protein Design at the University of Washington, compares protein design to the advent of custom tool-making. At some point, proto-humans went beyond merely finding uses for pieces of wood, rock or bone, and started designing tools to suit specific needs — from screwdrivers to sports cars.

Continue reading “Protein Engineering May Be the Future of Science” »

https://www.youtube.com/watch?v=9zr2_XrOX6E

Continue reading “Bioquark Inc. — Evolution of the New SuperHuman — Ira Pastor” »