Lifeboat Foundation

I was recently a co-author on a paper about anticipatory governance and genome editing. The lead author was Jon Rueda, and the others were Seppe Segers, Jeroen Hopster, Belén Liedo, and Samuela Marchiori. It’s available open access here on the Journal of Medical Ethics website. There is a short (900 word) summary available on the JME blog. Here’s a quick teaser for it:

Transformative emerging technologies pose a governance challenge. Back in 1980, a little-known academic at the University of Aston in the UK, called David Collingridge, identified the dilemma that has come to define this challenge: the control dilemma (also known as the ‘Collingridge Dilemma’). The dilemma states that, for any emerging technology, we face a trade-off between our knowledge of its impact and our ability to control it. Early on, we know little about it, but it is relatively easy to control. Later, as we learn more, it becomes harder to control. This is because technologies tend to diffuse throughout society and become embedded in social processes and institutions. Think about our recent history with smartphones. When Steve Jobs announced the iPhone back in 2007, we didn’t know just how pervasive and all-consuming this device would become. Now we do but it is hard to put the genie back in the bottle (as some would like to do).

The field of anticipatory governance tries to address the control dilemma. It aims to carefully manage the rollout of an emerging technology so as to avoid the problem of losing control just as we learn more about the effects of the technology. Anticipatory governance has become popular in the world of responsible innovation and design. In the field of bioethics, approaches to anticipatory governance often try to anticipate future technical realities, ethical concerns, and incorporate differing public opinion about a technology. But there is a ‘gap’ in current approaches to anticipatory governance.

Women are now being diagnosed with cancer more often than men in certain age groups, according to a new report from the American Cancer Society.

Among adults aged 50–64, cancer rates are slightly higher in women, and women under 50 are almost twice as likely as men in the same age group to receive a cancer diagnosis.

The report, released Thursday, found that while deaths continue to decrease, troubling racial disparities persist, with white Americans more likely to survive cancer than other groups.

AI-powered DIMON solves complex equations faster, boosting medical diagnostics and engineering simulations.

A new twist on a decades-old anticancer strategy has demonstrated significant potential against various cancer types in a preclinical study conducted by researchers at the Perelman School of Medicine at the University of Pennsylvania

The University of Pennsylvania (Penn) is a prestigious private Ivy League research university located in Philadelphia, Pennsylvania. Founded in 1740 by Benjamin Franklin, Penn is one of the oldest universities in the United States. It is renowned for its strong emphasis on interdisciplinary education and its professional schools, including the Wharton School, one of the leading business schools globally. The university offers a wide range of undergraduate, graduate, and professional programs across various fields such as law, medicine, engineering, and arts and sciences. Penn is also known for its significant contributions to research, innovative teaching methods, and active campus life, making it a hub of academic and extracurricular activity.

Researchers publishing in Physical Review X have discovered compounds that can double the efficiency of the sirtuin SIRT3 in processing NAD+.

Looking for a new way to boost enzymes

The researchers begin their paper by noting that most drugs administered to people are geared towards inhibition of particular enzymes in order to treat a disease. In this case, however, the goal is the opposite: to boost the function of an enzyme, thereby boosting a healthy phenotype rather than battling back a diseased one.

Summary: A study analyzing data from over 2 million veterans found that GLP-1 receptor agonists, popular weight-loss drugs like Ozempic and Wegovy, provide significant neurological and behavioral health benefits, including reduced risks of addiction, Alzheimer’s, and dementia. However, they also pose risks for pancreatitis and kidney conditions, emphasizing the need for careful monitoring.

The drugs mimic hormones that curb appetite and aid weight loss but may act on brain regions tied to impulse control and inflammation, explaining their broad effects. Researchers stress that while the benefits are modest, they may be impactful for conditions with limited treatment options, highlighting both their potential and limitations.

A new way of interpreting standard blood tests could help doctors spot cancer warning signs sooner, according to scientists.

Experts believe it could flag 10,000 patients a year who have a raised blood platelet count before their cancer diagnosis — leading to ‘earlier diagnosis and better patient outcomes’

Groundbreaking research uses brain stimulation to restore touch in prosthetics. Precise, stable sensations bring natural-like feedback closer, improving motor control and quality of life.

Summary: Researchers are making strides in restoring touch sensations to prosthetic limbs through brain stimulation. By using electrodes in the brain’s touch center, they can evoke stable, precise sensations, even allowing users to feel the shape and motion of objects.

This breakthrough could enable prosthetic users to perform tasks requiring fine motor control with confidence. Long-term tests show consistent sensation locations, critical for real-world usability.

Continue reading “Advancing Prosthetics: Restoring Touch Through Brain Stimulation” »

A small dose of low-power laser light activated dental stem cells in rat molars to generate dentin, one of the major components of teeth. The finding may lead to new approaches to develop low-cost, non-invasive therapies for treating dental disease and tooth damage.

Dentists currently use inert materials to repair damaged teeth. Tissue regeneration would be an attractive alternative, because inert materials can fail with time and don’t provide the full function of the tissue. Stimulating regeneration of teeth, however, is a major challenge. Teeth are composed of several parts, including the pulp at the core, dentin in the middle, and enamel on the surface.

Stem cells, found throughout the body, can give rise to specialized cells. Researchers have been able to coax stem cells to transform (differentiate) into many types of cells in the laboratory before infusing them into the body. But these techniques are time consuming and can bring unwanted side effects.