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Archive for the ‘biotech/medical’ category: Page 43

Nov 22, 2024

Repair Proteins Collaborate in “Hubs” to Repair DNA Damage

Posted by in categories: biotech/medical, chemistry

DNA can be damaged by normal cellular processes as well as external factors such as UV radiation and chemicals. Such damage can lead to breaks in the DNA strand. If DNA damage is not properly repaired, mutations can occur, which may result in diseases like cancer. Cells use repair systems to fix this damage, with specialized proteins locating and binding to the damaged regions. Now, researchers from the Kind Group at the Hubrecht Institute have mapped the activity of repair proteins in individual human cells. The study demonstrates how these proteins collaborate in so-called “hubs” to repair DNA damage. These findings may lead to new cancer therapies and other treatments where DNA repair is essential.

The researchers published their findings in Nature Communications in an article titled, “Genome-wide profiling of DNA repair proteins in single cells.”

“Accurate repair of DNA damage is critical for maintenance of genomic integrity and cellular viability,” the researchers wrote. “Because damage occurs non-uniformly across the genome, single-cell resolution is required for proper interrogation, but sensitive detection has remained challenging. Here, we present a comprehensive analysis of repair protein localization in single human cells using DamID and ChIC sequencing techniques.”

Nov 22, 2024

Frontiers: As we age, our immune system’s ability to effectively respond to pathogens declines, a phenomenon known as immunosenescence

Posted by in categories: biotech/medical, life extension, sex

This age-related deterioration affects both innate and adaptive immunity, compromising immune function and leading to chronic inflammation that accelerates aging. Immunosenescence is characterized by alterations in immune cell populations and impaired functionality, resulting in increased susceptibility to infections, diminished vaccine efficacy, and higher prevalence of age-related diseases. Chronic low-grade inflammation further exacerbates these issues, contributing to a decline in overall health and resilience. This review delves into the characteristics of immunosenescence and examines the various intrinsic and extrinsic factors contributing to immune aging and how the hallmarks of aging and cell fates can play a crucial role in this process. Additionally, it discusses the impact of sex, age, social determinants, and gut microbiota health on immune aging, illustrating the complex interplay of these factors in altering immune function. Furthermore, the concept of immune resilience is explored, focusing on the metrics for assessing immune health and identifying strategies to enhance immune function. These strategies include lifestyle interventions such as diet, regular physical activity, stress management, and the use of gerotherapeutics and other approaches. Understanding and mitigating the effects of immunosenescence are crucial for developing interventions that support robust immune responses in aged individuals.

The immune system plays a crucial role in protecting our bodies from harmful pathogens. It is divided into two segments: innate immunity and adaptive immunity. The innate immune system acts as an immediate but non-specific first responder to defend against pathogens, composed of phagocytic and natural killer cells. Besides innate immune cells, another important component of the innate system includes physical barriers like skin and mucous membranes. Meanwhile, adaptive immunity is more specialized and requires time to mount a high-affinity and specific response, relying on anticipatory receptors that recognize pathogen-specific antigens. The adaptive immune response is centered around B and T lymphocytes, which are produced in the bone marrow and thymus, respectively (Farber, 2020; Lam et al., 2024). With age, the ability of our immune system to mount productive and timely responses to pathogens diminishes.

Nov 22, 2024

Dr. Anirban Maitra is Advancing Early Detection and Cancer Interception in Pancreatic Tumors

Posted by in categories: biotech/medical, futurism

Dr. Anirban Maitra is a Professor of Pathology and Translational Molecular Pathology at MD Anderson Cancer Center. His research focuses on the early detection and treatment of pancreatic cancer.

Originally studying pediatric pathology, Dr. Maitra’s career trajectory changed upon attending a seminar on pancreatic cancer, which motivated him to address knowledge gaps in the disease’s biology. He wanted to explore the molecular and clinical aspects of the disease for the sake of improving patient prognosis. “This is a disease where there’s an opportunity to make a huge difference,” said Dr. Maitra.

Later, Dr. Maitra’s lab developed a pancreatic cancer liquid biopsy method, which is a non-invasive blood test that detects the presence of tumors. “There’s still a long way to go, but now we know what to look for and who to look in,” said Dr. Maitra regarding the future direction of pancreatic cancer detection.

Nov 22, 2024

New ion speed record holds potential for faster battery charging, biosensing

Posted by in categories: biotech/medical, computing

Scientists at Washington State University and Lawrence Berkeley National Laboratory have discovered a way to make ions move more than ten times faster in mixed organic ion-electronic conductors. These conductors combine the advantages of the ion signaling used by many biological systems, including the human body, with the electron signaling used by computers.

The new development, detailed in the journal Advanced Materials, speeds up ion movement in these conductors by using molecules that attract and concentrate ions into a separate nanochannel creating a type of tiny “ion superhighway.”

Nov 22, 2024

Researchers define new subtypes of common brain disorder

Posted by in categories: biotech/medical, robotics/AI

An MRI scan shows a Chiari type-1 malformation, in which the cerebellum extends beyond the gap in the skull where it connects to the spinal cord.


Artificial intelligence identified 3 subtypes of Chiari type-1 malformations, could improve medical decision making.

Nov 22, 2024

Nationwide IV fluid shortage could change how hospitals manage patient hydration

Posted by in categories: biotech/medical, health

Hospitals around the country are conserving critical intravenous fluid supplies to cope with a shortage that may last months. Some hospital administrators say they are changing how they think about IV fluid hydration altogether.

Hurricane Helene, which hit North Carolina in September, wrecked a Baxter International facility that produces 60% of the IV fluids used in the U.S., according to the American Hospital Association.

The company was forced to stop production and is rationing its products. In an update posted Nov. 7, Baxter said its North Cove facility had resumed producing some IV fluids. In an email to KFF Health News, the company wrote that customers will be able to order normal quantities of “certain IV solutions products” by the end of the year, but there is no timeline for when the North Cove facility will be back to prehurricane production levels.

Nov 22, 2024

HIMSSCast: Care provider or tool? When and why patients like AI

Posted by in categories: biotech/medical, robotics/AI

But according to recent research into patient attitudes on AI, providers should be thinking carefully about how they deploy those tools if they want to preserve patient trust.

Earlier this fall, Mark Polyak, president of analytics at IPSOS, and Dr. Lukasz Kowalczyk, a physician at Peak Gastroenterology Associates, spoke on a panel discussion at the HIMSS AI in Healthcare Forum that explored patients’ perspectives and attitudes about healthcare AI. Above all, they’re seeking healthcare interactions and experiences that are transparent and personalized, experts on the panel said.

Nov 22, 2024

Gene regulation study reports surprising results: Extensive regions of DNA belong to multiple gene switches

Posted by in categories: biotech/medical, evolution

Some sequences in the genome cause genes to be switched on or off. Until now, each of these gene switches, or so-called enhancers, was thought to have its own place on the DNA. Different enhancers are therefore separated from each other, even if they control the same gene, and switch it on in different parts of the body.

A recent study from the University of Bonn and the LMU Munich challenges this idea. The findings are also important because gene switches are thought to play a central role in evolution. The study has been published in the journal Science Advances.

The blueprint of plant and animal forms is encoded in their DNA. But only a small part of the genome—about two percent in mammals—contains genes, the instructions for making proteins. The rest largely controls when and where these genes are active: how many of their transcripts are produced, and thus how many proteins are made from these transcripts.

Nov 22, 2024

Using gas bubbles to precisely deliver nanomedicines shows promise for lung cancer treatment

Posted by in category: biotech/medical

The delivery of nanomedicines using gas bubbles has shown itself to be a unique way of transporting cytotoxins to the lungs of cancer patients. The method enables precise and focused treatments, and the local action of the drugs also prevents a range of side-effects.

Nov 22, 2024

Optoelectronic device mimics human vision for diversified in-sensor computing

Posted by in categories: biotech/medical, computing, neuroscience

Researchers at Karolinska Institutet and Karolinska University Hospital have developed a microscopy method that enables detailed three-dimensional (3D) RNA analysis at cellular resolution in whole intact mouse brains. The new method, called TRISCO, has the potential to transform our understanding of brain function, both in normal conditions and in disease, according to a new study published in Science.

Despite great advances in RNA analysis, linking RNA data to its spatial context has long been a challenge, especially in intact 3D tissue volumes. The TRISCO method now makes it possible to perform three-dimensional RNA imaging of whole mouse brains without the need to slice the brain into thin sections, which was previously necessary.

“This method is a powerful tool that can drive forward. With TRISCO, we can study the complex anatomical structure of the brain in a way that was previously not possible,” says Per Uhlén, professor at the Department of Medical Biochemistry and Biophysics, Karolinska Institutet, and the study’s last author.

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