Lifeboat Foundation

Actin, a family of proteins that help give cells their shape, are abundant throughout the body.

Humans aren’t the only ones who grow forgetful as they age—fruit flies do, too. But because fruit flies have a lifespan of only about two months, they can be a useful model for understanding the cognitive decline that comes with aging.

A new study published in Nature Communications shows that when a common cell structural protein called filamentous actin, or F-actin, builds up in the brain, it inhibits a key process that removes unnecessary or dysfunctional components within cells, including DNA, lipids, proteins and organelles.

Continue reading “Scientists can reverse brain aging in fruit flies by preventing buildup of a common protein” »

There are rare cells in the gut called enteroendocrine cells (EECs) that could be manipulated in a variety of ways to detect or treat disease.

The trillions of microbes in our gastrointestinal tract, known as the gut microbiome, are crucial to the body; the gut microbiome aids in digestion, nutrient absorption, and influences our health in different ways. But the body also has to be protected from all of those microbes, which are kept behind a tight barrier. But if the intestinal barrier is dysfunctional, or leaky, serious problems can arise.

Continue reading “How Rare Intestinal Cells May Work as a Kind of Therapeutic Sensor” »

Organization runs deep in our family tree, if we use the literal definition of “organize”: to be furnished with organs. Eukaryotes emerged billions of years ago, bringing with them the copious benefits of compartmentalization.

All modern multicellular life — all life that any of us regularly see — is made of cells with a knack for compartmentalization. Recent discoveries are revealing how the first eukaryote got its start.

One prevailing hypothesis is that physical fitness mitigates structural brain changes that contribute to cognitive decline. Recent evidence points to a potential role involving myelin —the insulating sheath surrounding neurons that is crucial for efficient neural signaling and overall cognitive health. Myelination facilitates rapid signal transmission and supports neural network integrity.

The degeneration of myelin in the brain is increasingly recognized as a critical factor contributing to disruptions in neural communication, which may play a significant role in the cognitive decline observed in Alzheimer’s disease and other neurodegenerative disorders. Emerging research suggests that myelin breakdown may even precede the formation of amyloid-beta plaques and neurofibrillary tangles—the hallmark pathological features of Alzheimer’s disease. Advanced imaging studies have detected early myelin degeneration in individuals who later develop Alzheimer’s, indicating that myelin damage could be an initial event in the disease’s progression.

Age-related deterioration of myelin is closely associated with cognitive decline. Reduced white matter integrity—often resulting from myelin damage—is correlated with declines in memory, executive function, and processing speed in older adults. As myelin degradation leads to the slowing of cognitive processes and disrupts the synchronization of neural networks, preserving myelin integrity is essential for sustaining cognitive health across the lifespan.

What keeps some immune systems youthful and effective in warding off age-related diseases? In a new paper published in Cellular & Molecular Immunology, USC Stem Cell scientist Rong Lu and her collaborators point the finger at a small subset of blood stem cells, which make an outsized contribution to maintaining either a youthful balance or an age-related imbalance of the two main types of immune cells: innate and adaptive.

Innate immune cells serve as the body’s first line of defense, mobilizing a quick and general attack against invading germs. For germs that evade the body’s innate immune defenses, the second line of attack consists of adaptive immune cells, such as B cells and T cells that rely on their memory of past infections to craft a specific and targeted response. A healthy balance between innate and adaptive immune cells is the hallmark of a youthful immune system—and a key to longevity.

“Our study provides compelling evidence that when a small subset of blood stem cells overproduces innate immune cells, this drives the aging of the immune system, contributes to disease, and ultimately shortens the lifespan,” said Lu, who is an associate professor of stem cell biology and regenerative medicine, biomedical engineering, medicine, and gerontology at USC, and a Leukemia & Lymphoma Society Scholar. Lu is also a member of the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, and the USC Norris Comprehensive Cancer Center at the Keck School of Medicine of USC.

The generation and maintenance of protective immunity is a dynamic interplay between host and environment that is impacted by age. Understanding fundamental changes in the healthy immune system that occur over a lifespan is critical in developing interventions for age-related susceptibility to infections and diseases. Here, we use multi-omic profiling (scRNA-seq, proteomics, flow cytometry) to examined human peripheral immunity in over 300 healthy adults, with 96 young and older adults followed over two years with yearly vaccination. The resulting resource includes scRNA-seq datasets of 16 million PBMCs, interrogating 71 immune cell subsets from our new Immune Health Atlas. This study allows unique insights into the composition and transcriptional state of immune cells at homeostasis, with vaccine perturbation, and across age. We find that T cells specifically accumulate age-related transcriptional changes more than other immune cells, independent from inflammation and chronic perturbation. Moreover, impaired memory B cell responses to vaccination are linked to a Th2-like state shift in older adults’ memory CD4 T cells, revealing possible mechanisms of immune dysregulation during healthy human aging. This extensive resource is provided with a suite of exploration tools at https://apps.allenimmunology.org/aifi/insights/dynamics-imm-health-age/ to enhance data accessibility and further the understanding of immune health across age.

A.W.G. serves on the scientific advisory boards of ArsenalBio and Foundery Innovations.

In 2017, Jacob Haendel was living a normal life as a head chef in…

A paralysed man who had an extreme form of locked-in syndrome and heard a nurse say he was “brain dead” has become the first ever to recover after hearing medical professionals debating whether or not to switch off his life support.

In 2017, Jacob Haendel was living a normal life as a head chef in Boston, Massachusetts but in the space of a few weeks, his life was turned upside down after he was diagnosed with acute toxic progressive leukoencephalopathy, which progressed into locked-in syndrome and forced his body would slowly shut down. An extreme form of locked-in syndrome is a condition where a patient is aware but cannot move or communicate verbally due to complete paralysis and can be caused by brain trauma, infection or exposure to toxins.

Continue reading “‘Brain dead’ man trapped in body heard debate about turning off his life support” »

The type of semiconductive nanocrystals known as quantum dots are both expanding the forefront of pure science and also hard at work in practical applications including lasers, quantum QLED televisions and displays, solar cells, medical devices, and other electronics.

As technology advances, the limitations of conventional electronic computers are becoming increasingly apparent, especially when tackling complex computational challenges. NP-complete problems, which grow exponentially with size, represent some of the toughest puzzles in computer science. These issues have significant implications across various fields, including biomedicine, transportation, and manufacturing. In the quest for more effective…