Lifeboat Foundation

It is well-established that chronic MSK pain is the key factor for physical disability in the adult population. ¹⁹ The World Health Organization (WHO) estimates that 20–33% (over 1.71 billion individuals) of the global population suffers from chronic MSK pain. ²⁰ This type of disorder is characterized by acute or chronic pain in MSK structures, which involve muscles, tendons, ligaments, bones, and nerves. ²¹ The most common conditions responsible for visits to a physician’s office are OA, rheumatoid arthritis, myofascial pain syndrome (MPS), and low back and neck pain. ²² Less common incidents are generally accompanying with injuries like of tendon sprains, ligament tears, muscle tears, fractures, and similar damage during sports. ²⁰

If left untreated, these conditions progressively increase suffering, disability, and drug consumption, which subsequently diminish an individual’s quality of life. ²³ This also translates to a main community health problem due to significant high expenses for health-care systems and insurance for disability. Advanced age may remain the top variable associated with the increased risk of musculoskeletal disorders (MSDs) and MSK pain; however, these conditions may still unfold at any given age for various reasons. Therefore, every individual is at risk of experiencing MSK pain throughout an entire lifetime. ²⁴ Acute pain can become chronic due to numerous factors. The level of intensity, site, and time of noxious stimuli are dictated by the interplay between mechanical, chemical, and thermal receptors and immune cells. ²⁵ Under standard conditions, noxious stimuli and painful sensations gradually decrease with the progression of healing.

King Frederik X of Denmark practically called Huang a king with a leather jacket on.

A new framework bridges a gap in understanding RNA therapeutics by linking the structure of lipid nanoparticles to immune response. It can help scientists and engineers expand the use of RNA medicines beyond vaccines to other therapeutic applications.

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By Chuck Brooks, Skytop Contributor / October 25, 2024

Chuck Brooks serves as President and Consultant of Brooks Consulting International. Chuck also serves as an Adjunct Professor at Georgetown University in the Cyber Risk Management Program, where he teaches graduate courses on risk management, homeland security, and cybersecurity.

Chuck has received numerous global accolades for his work and promotion of cybersecurity. Recently, he was named the top cybersecurity expert to follow on social media, and also as one top cybersecurity leaders for 2024. He has also been named “Cybersecurity Person of the Year” by Cyber Express, Cybersecurity Marketer of the Year, and a “Top 5 Tech Person to Follow” by LinkedIn” where he has 120,000 followers on his profile.

As a thought leader, blogger, and event speaker, he has briefed the G20 on energy cybersecurity, The US Embassy to the Holy See, and the Vatican on global cybersecurity cooperation. He has served on two National Academy of Science Advisory groups, including one on digitalizing the USAF, and another on securing BioTech. He has also addressed USTRANSCOM on cybersecurity and serves on an industry/government Working group for DHS CISA focused on security space systems.

In the movie “Jurassic Park,” scientists extracted DNA that had been preserved in amber for millions of years, and used it to create a population of long-extinct dinosaurs.

Researchers at The Jackson Laboratory (JAX), the Broad Institute of MIT and Harvard, and Yale University, have used artificial intelligence to design thousands of new DNA switches that can precisely control the expression of a gene in different cell types. Their new approach opens the possibility of controlling when and where genes are expressed in the body, for the benefit of human health and medical research, in ways never before possible.

“What is special about these synthetically designed elements is that they show remarkable specificity to the target cell type they were designed for,” said Ryan Tewhey, PhD, an associate professor at The Jackson Laboratory and co-senior author of the work. “This creates the opportunity for us to turn the expression of a gene up or down in just one tissue without affecting the rest of the body.”

In recent years, genetic editing technologies and other gene therapy approaches have given scientists the ability to alter the genes inside living cells. However, affecting genes only in selected cell types or tissues, rather than across an entire organism, has been difficult. That is in part because of the ongoing challenge of understanding the DNA switches, called cis-regulatory elements (CREs), that control the expression and repression of genes.

Scientists have identified a natural compound that halts the process involved in the progression of certain forms of cancer and demyelinating conditions—those that damage the sheath, known as myelin, that surrounds neurons—such as multiple sclerosis.

ABOVE: The placenta’s labyrinth zone (red), responsible for nutrient exchange between mother and fetus, is reduced in fetuses with dysbiotic fathers (lower panel) compared to healthy fathers (upper panel). Ayele Argaw-Denboba.

The microbiome has a profound impact on host health that extends to the host’s young ones. Studies in mice have shown that maternal gut bacteria play a role in offspring behavior and placental growth during pregnancy.^1,2 Yet, the effects of the paternal microbiome on the health of their progeny remained relatively unexplored.

In a new study, scientists found that altering the gut microbiome of male mice negatively affected the health and lifespan of their offspring through epigenetic changes in the sperm.³ The results, published in Nature, offer insights into a gut-germline axis that mediates the effects of the microbiome on health and disease across generations.