Lifeboat Foundation

Every time a cell divides, its DNA is duplicated so that the two daughter cells have the same genetic material as their parent. This means that, millions of times a day, a biochemical wonder takes place in the body: the copying of the DNA molecule. It is a high-precision job carried out by specific proteins and includes systems to protect against potential errors that could lead to diseases such as cancer.

One of these anti-failure systems has just been discovered by researchers in the DNA Replication Group at the Spanish National Cancer Research Centre (CNIO), led by Juan Méndez. It is based on a protein that ensures that DNA is copied only once, as it should be, and not twice or more.

The work is published in The EMBO Journal.

Scientists from the University of Rochester have developed new electrochemical approaches to clean up pollution from “forever chemicals” found in clothing, food packaging, firefighting foams, and a wide array of other products. A new Journal of Catalysis study describes nanocatalysts developed to remediate per-and polyfluoroalkyl substances known as PFAS.

The researchers, led by assistant professor of chemical engineering Astrid Müller, focused on a specific type of PFAS called Perfluorooctane sulfonate (PFOS), which was once widely used for stain-resistant products but is now banned in much of the world for its harm to human and animal health. PFOS is still widespread and persistent in the environment despite being phased out by US manufacturers in the early 2000s, continuing to show up in water supplies.

In an article published in the Journal of Materials Chemistry C, Brazilian researchers describe a strategy to enhance the efficiency and stability of solar cells made of perovskite, a semiconductor material produced in the laboratory. The results of the project could be highly positive for the future of the solar power sector.

Developed by researchers at São Paulo State University (UNESP) in Bauru, Brazil, the method involves the use of a class of materials known as MXenes, a family of two-dimensional materials with a graphene-like structure combining transition metals, carbon and/or nitrogen, and surface functional groups such as fluoride, oxygen or hydroxyl. Their properties include high electrical conductivity, good thermal stability, and high transmittance (relating to the amount of light that passes through a substance without being reflected or absorbed).

In the study, the MXene Ti3C2Tx was added to polymethyl methacrylate (PMMA) to form a passivation coating, which was spin-coated on top of the perovskite layer of inverted solar cells. Passivation coatings are designed to mitigate possible defects in polycrystalline solids (perovskite in this case) due to interaction with the environment or to their internal structure.

Robots and cameras of the future could be made of liquid crystals, thanks to a new discovery that significantly expands the potential of the chemicals already common in computer displays and digital watches.

The findings, a simple and inexpensive way to manipulate the molecular properties of liquid crystals with light exposure, are now published in Advanced Materials.

“Using our method, any lab with a microscope and a set of lenses can arrange the liquid crystal alignment in any pattern they’d want,” said author Alvin Modin, a doctoral researcher studying physics at Johns Hopkins. “Industrial labs and manufacturers could probably adopt the method in a day.”

Quantum computers promise to efficiently predict the structure and behaviour of molecules. This Perspective explores how this could overcome existing challenges in computational drug discovery.

Scientists at the National University of Singapore (NUS) have created a microporous covalent organic framework with dense donor–acceptor lattices and engineered linkages for the efficient and clean production of hydrogen peroxide (H₂O₂) through the photosynthesis process with water and air.

Traditional industrial production of H₂O₂ via the anthraquinone process using hydrogen and oxygen, is highly energy-intensive. This approach employs toxic solvents and expensive noble-metal catalysts, and generates substantial waste from side reactions.

Paclitaxel is the world’s best-selling plant-based anticancer drug and one of the most effective anticancer drugs over the past 30 years. It is widely used in the treatment of various types of cancer, including breast cancer, lung cancer, and ovarian cancer.

In the late 1990s and early 21st century, the annual sales of paclitaxel exceeded $1.5 billion and reached $2.0 billion in 2001, making it the best-selling drug in 2001. In 2019, the market for paclitaxel and its derivatives was approximately $15 billion, and it is expected to reach $20 billion by 2025.

As an anticancer drug, the molecular structure of paclitaxel is extremely complex, with highly oxidized, intricate bridged rings and 11 stereocenters, making it widely recognized as one of the most challenging natural products to synthesize chemically. Since the first total synthesis of paclitaxel was reported by the Holton and Nicolaou research groups in 1994, more than 40 research teams have been engaged in the total synthesis of paclitaxel.

“Enriched cosmic dust, on the other hand, I think makes for a plausible source.”

Dr. Walton’s team now plans to test their theory experimentally, using large reaction vessels to recreate the conditions that might have prevailed in the primeval melt holes, then setting the initial conditions to those that probably existed in a cryoconite hole four billion years ago before waiting to see whether any chemical reactions of the kind that produce biologically relevant molecules do indeed develop.

The post Scientists say cosmic dust may have kick-started life on Earth appeared first on Talker.

A pair of chemists at the University of Groningen in the Netherlands, has observed communication between rotors in a molecular motor. In their study, reported in the Journal of the American Chemical Society, Carlijn van Beek and Ben Feringa conducted experiments with alkene-based molecular motors.

Molecular motors are natural or artificial molecular machines that convert energy into movement in living organisms. One example would be DNA polymerase turning single-stranded DNA into double-stranded DNA. In this new effort, the researchers were experimenting with light-driven, alkene-based molecular motors, using light to drive molecular rotors. As part of their experiments, they created a motor comprising three gears and two rotors and observed an instance of communication between two of the rotors.

To build their motor, the researchers started with parts of existing two motors, bridging them together. The resulting isoindigo structure, they found, added another dimension to their motor relative to other synthesized motors—theirs had a doubled, metastable intermediary connecting two of the rotors, allowing for communication between the two.