Lifeboat Foundation

A study by chemists at the University of Chicago has uncovered a new key step in the process that HIV uses to replicate itself.

The study, published Jan. 6 in Science Advances, used computer modeling to focus on how HIV forms a capsule that carries its genetic material—in particular, the role of a particular ion known as IP6. Scientists had previously suspected IP6 has an important function but didn’t know exactly how it worked.

Continue reading “Tiny ion is crucial for HIV replication, say chemists” »

Physical systems evolve at a particular speed, which depends on various factors including the system’s so-called topological structure (i.e., spatial properties that are preserved over time despite any physical changes that occur). Existing methods for determining the speed at which physical systems change over time, however, do not account for these structural properties.

Two researchers at Keio University in Japan have recently derived a speed limit for the evolution of physical states that also accounts for the topological structure of a system and of its underlying dynamics. This speed limit, outlined in a paper published in Physical Review Letters, could have numerous valuable applications for the study and development of different physical systems, including quantum technologies.

“Figuring out how fast a system state can change is a central topic in classical and quantum mechanics, which has attracted the great interest of scientists,” Tan Van Vu and Keiji Saito, the researchers who carried out the study, told Phys.org. “Understanding the mechanism of controlling time is relevant to engineering fast devices such as quantum computers.”

Paris-based quantum computing startup PASQAL announced today it has raised €100 million in a Series B funding round, led by a new investor, Singapore-based Temasek. It was joined by the European Innovation Council (EIC) Fund, Wa’ed Ventures and Bpifrance, through its Large Venture Fund and existing investors Quantonation, the Defense Innovation Fund, Daphni and Eni Next. This brings PASQAL’s total funding to date to more than €140 million.

Founded in 2019 as a spin-off from Institut d’Optique, PASQAL develops quantum processors based on ordered neutral atoms in 2D and 3D arrays. Physics Today.

PASQAL’s technology is based on research conducted by the winner of the 2022 Nobel Prize in Physics, and it plans to deliver major commercial advantages over classical computers by 2024.

Continue reading “A ‘Dark Horse’ In The Quantum Computing Race Raises €100 Million” »

Dr. Cody reveals private conversations about BCI and experience at CES2023.

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Continue reading “A Billionaire and Brain Computer Interface: Behind the Scenes at Consumer Electronic Show 2023” »

What’s your favorite number? There are literally infinite options, and yet only a few which seem to stand out as more popular than others: there’s seven, obviously; 13 or 666 for the badasses among us; and √2 for anyone who just likes annoying Pythagoreans.

But there’s really only one number out there that can claim to be World Champion: pi. What other mathematical constant is literally used as a benchmark for computing power, or forms the basis for a never-ending worldwide grudge match over who can list the most random digits in the correct order (current record: 111,700)?

The reason pi is able to capture our imagination like this is because it is an irrational number – in other words, its decimal expansion is never-ending and entirely random. It’s thought that any sequence of numbers you can possibly think of can be found somewhere in the expansion of pi, and yet knowing any particular sequence somewhere in the expansion tells you no information about which digit comes next.

Large Language Models (LLM) are on fire, capturing public attention by their ability to provide seemingly impressive completions to user prompts (NYT coverage). They are a delicate combination of a radically simplistic algorithm with massive amounts of data and computing power. They are trained by playing a guess-the-next-word game with itself over and over again. Each time, the model looks at a partial sentence and guesses the following word. If it makes it correctly, it will update its parameters to reinforce its confidence; otherwise, it will learn from the error and give a better guess next time.

While the underpinning training algorithm remains roughly the same, the recent increase in model and data size has brought about qualitatively new behaviors such as writing basic code or solving logic puzzles.

How do these models achieve this kind of performance? Do they merely memorize training data and reread it out loud, or are they picking up the rules of English grammar and the syntax of C language? Are they building something like an internal world model—an understandable model of the process producing the sequences?

True to Moore’s Law, the number of transistors on a microchip has doubled every year since the 1960s. But this trajectory is predicted to soon plateau because silicon — the backbone of modern transistors — loses its electrical properties once devices made from this material dip below a certain size.

Enter 2D materials — delicate, two-dimensional sheets of perfect crystals that are as thin as a single atom. At the scale of nanometers, 2D materials can conduct electrons far more efficiently than silicon. The search for next-generation transistor materials therefore has focused on 2D materials as potential successors to silicon.

But before the electronics industry can transition to 2D materials, scientists have to first find a way to engineer the materials on industry-standard silicon wafers while preserving their perfect crystalline form. And MIT engineers may now have a solution.

A recently discovered acoustic effect allows a hot gas to simulate the gravity-induced convection within a star or giant planet.

Sometimes a light bulb goes on—literally—and a scientific advance is made. Researchers studying an acoustic effect in high-powered light bulbs have developed a system that mimics the gravitational field around planets and stars [1]. The team demonstrated that sound waves in the bulb generate a force that pulls gas toward the bulb’s center. This gravity-like force causes the gas to move around in convection cycles that resemble fluid flows in the Sun and in giant planets. With further improvements, the system could be used to investigate convection behavior that is too difficult to simulate with computers.

In 2017, research on high-powered sulfur lamps revealed that sound waves could drive hot gas to ball up in the center of the bulbs [2]. The surprising phenomenon caught the attention of Seth Putterman’s acoustic group at the University of California, Los Angeles. The team studied the clumping and showed that it could be explained by the acoustic radiation force. This force is well known in acoustic levitation experiments, in which sound waves scattering off an object, such as a small bead, can exert a force (see Synopsis: Tossing and Turning). Putterman and his colleagues showed that, in the bulbs, this force acts not at the surface of an object where sound scatters, but throughout the gas, where density variations redirect the sound waves. “We knew that the force acts at a sharp interface between something solid and a gas,” says team member John Koulakis. “In the bulb, there’s no sharp interface—just variations—but there still is a force.”

On the journey from gene to protein, a nascent RNA molecule can be cut and joined, or spliced, in different ways before being translated into a protein. This process, known as alternative splicing, allows a single gene to encode several different proteins. Alternative splicing occurs in many biological processes, like when stem cells mature into tissue-specific cells. In the context of disease, however, alternative splicing can be dysregulated. Therefore, it is important to examine the transcriptome—that is, all the RNA molecules that might stem from genes—to understand the root cause of a condition.

However, historically it has been difficult to “read” RNA molecules in their entirety because they are usually thousands of bases long. Instead, researchers have relied on so-called short-read RNA sequencing, which breaks RNA molecules and sequence them in much shorter pieces—somewhere between 200 to 600 bases, depending on the platform and protocol. Computer programs are then used to reconstruct the full sequences of RNA molecules.

Short-read RNA sequencing can give highly accurate sequencing data, with a low per-base error rate of approximately 0.1% (meaning one base is incorrectly determined for every 1,000 bases sequenced). Nevertheless, it is limited in the information that it can provide due to the short length of the sequencing reads. In many ways, short-read RNA sequencing is like breaking a large picture into many jigsaw pieces that are all the same shape and size and then trying to piece the picture back together.