Lifeboat Foundation

In a study published in Nucleic Acids Research, the team of cancer researcher Francis Rodier, an Université de Montréal professor, shows for the first time that cellular senescence, which occurs when aging cells stop dividing, is caused by irreversible damage to the genome rather than simply by telomere erosion.

This discovery goes against the scientific model most widely adopted in the last 15 years, which is based on one principle: telomeres, caps located at the ends of chromosomes whose purpose is to protect genetic information, erode with each cell division. When they get too short, they tell the cell to stop dividing, thus preventing damage to its DNA. Made dormant, the cell enters senescence.

For this model to be valid, the inactivation of a single telomere should be sufficient to activate the senescence program. Rodier’s laboratory and many others had already observed that several dysfunctional telomeres were necessary.

1. In a paper published on October 28 2021, in the peer-reviewed Journal of Heredity, scientists from the San Diego Zoo revealed that at least two California condors born over the last 40 years or so are biologically fatherless. A genetic database maintained since the 1980s showed no trace whatsoever of paternal genes in their DNA.

2. No one knows whether reproducing asexually is a new talent for California condors. Maybe the species has always been capable of it. California condors almost went extinct in the 1980s, and they are still endangered. Because of this, the number of animals in the genetic database is too small for anyone to address the question reasonably.

Dr. Yuval Noah Harari, macro-historian, Professor, best-selling author of “Sapiens” and “Homo Deus,” and one of the world’s most innovative and exciting thinkers, has a few hypotheses of his own on the future of humanity.

He examines what might happen to the world when old myths are coupled with new godlike technologies, such as artificial intelligence and genetic engineering.

Continue reading “Yuval Noah Harari on The Future of Humanity” »

The USA Government is secretly working on a real Anti Aging Pill which aims to extend peoples lifespan and improve their health. This new longevity research project even made Aubrey De Grey interested as he said in an interview. Although he’s working on other kinds of medication to make people live forever or at least to stop peoples aging.

Dr. David Sinclair’s main research interest is the epigenetics of aging, with a focus on epigenetic reprogramming of aging, NAD+ metabolism and sirtuins, and NAD+ precursors like NR and NMN. David Sinclair is also working on supplements that are supposed to slow down the aging process.
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Continue reading “THIS PILL makes you Live Forever — The Government’s Longevity Project” »

According to Klaus Schwab, the founder and executive chair of the World Economic Forum (WEF), the 4-IR follows the first, second, and third Industrial Revolutions—the mechanical, electrical, and digital, respectively. The 4-IR builds on the digital revolution, but Schwab sees the 4-IR as an exponential takeoff and convergence of existing and emerging fields, including Big Data; artificial intelligence; machine learning; quantum computing; and genetics, nanotechnology, and robotics. The consequence is the merging of the physical, digital, and biological worlds. The blurring of these categories ultimately challenges the very ontologies by which we understand ourselves and the world, including “what it means to be human.”

The specific applications that make up the 4-R are too numerous and sundry to treat in full, but they include a ubiquitous internet, the internet of things, the internet of bodies, autonomous vehicles, smart cities, 3D printing, nanotechnology, biotechnology, materials science, energy storage, and more.

While Schwab and the WEF promote a particular vision for the 4-IR, the developments he announces are not his brainchildren, and there is nothing original about his formulations. Transhumanists and Singularitarians (or prophets of the technological singularity), such as Ray Kurzweil and many others, forecasted these and more revolutionary developments,. long before Schwab heralded them. The significance of Schwab and the WEF’s take on the new technological revolution is the attempt to harness it to a particular end, presumably “a fairer, greener future.”

A team of physicists has discovered how DNA

DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

Many people develop Alzheimer’s or other forms of dementia as they get older. However, others remain sharp well into old age, even if their brains show underlying signs of neurodegeneration.

Among these cognitively resilient people, researchers have identified education level and amount of time spent on intellectually stimulating activities as factors that help prevent dementia. A new study by MIT researchers shows that this kind of enrichment appears to activate a gene family called MEF2, which controls a genetic program in the brain that promotes resistance to cognitive decline.

The researchers observed this link between MEF2 and cognitive resilience in both humans and mice. The findings suggest that enhancing the activity of MEF2 or its targets might protect against age-related dementia.

Evolutionary genomics approach identifies genes that enable plants to live in the Atacama Desert, offering clues for engineering more resilient crops to face climate change.

An international team of researchers has identified genes associated with plant survival in one of the harshest environments on Earth: the Atacama Desert in Chile. Their findings, published in Proceedings of the National Academy of Sciences (PNAS), may help scientists breed resilient crops that can thrive in increasingly drier climates.

“In an era of accelerated climate change, it is critical to uncover the genetic basis to improve crop production and resilience under dry and nutrient-poor conditions,” said Gloria Coruzzi, Carroll & Milton Petrie Professor in the New York University (NYU) Department of Biology and Center for Genomics and Systems Biology, who co-led the study with Rodrigo Gutiérrez.

Rare diseases aren’t so rare. Collectively, up to 30 million Americans, many of them children, are born with one of the approximately 7,000 known rare diseases. Most of these millions of people also share a common genetic feature: their diseases are caused by an alteration in a single gene.

Many of these alterations could theoretically be targeted with therapies designed to correct or replace the faulty gene. But there have been significant obstacles in realizing this dream. The science of gene therapy has been making real progress, but pursuing promising approaches all the way to clinical trials and gaining approval from the U.S. Food and Drug Administration (FDA) is still very difficult. Another challenge is economic: for the rarest of these conditions (which is most of them), the market is so small that most companies have no financial incentive to pursue them.

To overcome these obstacles and provide hope for those with rare diseases, we need a new way of doing things. One way to do things differently—and more efficiently—is the recently launched Bespoke Gene Therapy Consortium (BGTC). It is a bold partnership of NIH, the FDA, 10 pharmaceutical companies, and several non-profit organizations [1]. Its aim: optimize the gene therapy development process and help fill the significant unmet medical needs of people with rare diseases.