The more data collected, the better the results.
Understanding the genetics of complex diseases, especially those related to the genetic differences among ethnic groups, is essentially a big data problem. And researchers need more data.
1000, 000 genomes
Summary: Study reveals there are differences in genes and the genetic burdens that underpin ASD between males and females. Researchers also found specific differences in the ways the brains of girls on the autism spectrum respond to different social cues.
Source: University of Virginia.
New research has shed light on how autism-spectrum disorder (ASD) manifests in the brains of girls, prompting the scientists to warn that conclusions drawn from studies conducted primarily in boys should not be assumed to hold true for girls.
Sleepy head: Fruit flies with a gene mutation in the gene ISWI have poorly formed sleep circuits in their brains.
A gene that is poorly expressed in people with certain neurodevelopmental conditions is also essential for sleep, according to a new study in fruit flies.
Many people with autism or other neurodevelopmental conditions have trouble falling asleep and slumbering soundly. This difficulty is often viewed as a side effect of a given condition’s core traits, such as heightened sensory sensitivities and repetitive behaviors in autism.
The reality is Benny and Josh both have Canavan disease, a fatal inherited brain disorder. They are buckled into wheelchairs, don’t speak, and can’t control their limbs.
On Thursday, April 8, in Dayton, Ohio, Landsman and his family rolled the older boy, Benny, into a hospital where over several hours, neurosurgeons drilled bore holes into his skull and injected trillions of viral particles carrying the correct version of a gene his body is missing.
This spring, the biotechnology company Oxitec plans to release genetically modified (GM) mosquitoes in the Florida Keys. Oxitec says its technology will combat dengue fever, a potentially life-threatening disease, and other mosquito-borne viruses — such as Zika — mainly transmitted by the Aedes aegypti mosquito.
While there have been more than 7300 dengue cases reported in the United States between 2010 and 2020, a majority are contracted in Asia and the Caribbean, according to the U.S. Centers for Disease Control and Prevention. In Florida, however, there were 41 travel-related cases in 2020, compared with 71 cases that were transmitted locally.
Antisense oligonucleotide therapy works by altering the RNA, the messenger that carries instructions from your DNA to crank out proteins.
An article in Nature Reviews Neurology describes antisense oligonucleotides as “short, synthetic, single-strand” molecules, which can alter RNA to cause protein creation to be reduced, enhanced, or modified.
In the Penn study, the targeted protein was created by the mutated LCA gene.
New, reversible CRISPR method can control gene expression while leaving underlying DNA sequence unchanged.
Over the past decade, the CRISPR-Cas9 gene editing system has revolutionized genetic engineering, allowing scientists to make targeted changes to organisms’ DNA. While the system could potentially be useful in treating a variety of diseases, CRISPR-Cas9 editing involves cutting DNA strands, leading to permanent changes to the cell’s genetic material.
Now, in a paper published online in Cell on April 9, researchers describe a new gene editing technology called CRISPRoff that allows researchers to control gene expression with high specificity while leaving the sequence of the DNA unchanged. Designed by Whitehead Institute Member Jonathan Weissman, University of California San Francisco assistant professor Luke Gilbert, Weissman lab postdoc James Nuñez and collaborators, the method is stable enough to be inherited through hundreds of cell divisions, and is also fully reversible.
The gene editing system CRISPR-Cas9 makes breaks in DNA strands that are repaired by cells—a process that can be hard to control, resulting in unwanted genetic changes. Researchers at the Massachusetts Institute of Technology and the University of California, San Francisco (UCSF) designed an alternative technology that changes gene expression without damaging DNA, and they believe it could be useful for both research and drug development.
The researchers used their system, dubbed CRISPRoff and CRISPRon, to induce pluripotent stem cells to transform into neurons. They also used it to silence the gene that makes the protein Tau, which has been implicated in Alzheimer’s disease. They described their research in the journal Cell.
The MIT and UCSF researchers started by creating a machine made of a protein and small RNAs that guided it to specific spots on strands of DNA. The machine adds “methyl groups” to genes to silence their expression. The technology can also reverse the process, turning the genes back on by removing the methyl groups.
MSU’s expertise in fish biology, genetics helping researchers rewrite evolutionary history and shape future health studies.
The network of nerves connecting our eyes to our brains is sophisticated and researchers have now shown that it evolved much earlier than previously thought, thanks to an unexpected source: the gar fish.
Michigan State University’s Ingo Braasch has helped an international research team show that this connection scheme was already present in ancient fish at least 450 million years ago. That makes it about 100 million years older than previously believed.
O,.o.
The largest-ever study of almost 2000 DNA samples carried out by researchers at Pompeu Fabra university (UPF) in Barcelona has confirmed the “genetic singularity” of the Basques in Europe. The investigation, however, found that this difference only began to emerge 2500 years ago in the Iron Age. “Our analyses confirm that Basques were influenced by the major migration waves in Europe until the Iron Age, in a similar pattern as their surrounding populations,” the authors explain in the study published in the journal Current Biology.
The origin of the Basques has fascinated the scientific community since the 19th century. The French anthropologist Paul Broca snuck into a Basque cemetery one night in 1862 to steal skulls he wanted to study for their supposed genetic differences. Juan José Ibarretxe, premier of the Basque regional government until 2009, proclaimed that the Basque people “have existed for 7000 years” to promote his vision of an independent Basque state. And the then-president of the Basque Nationalist Party (PNV), Xabier Arzalluz, claimed in 2000 that the Basques were “the oldest inhabitants of Europe,” with “their own roots” since prehistoric times.
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