Lifeboat Foundation

Antibiotic resistance is a global threat to public health and associated with the overuse of antibiotics. Although non-antibiotic drugs occupy 95% of the drug market, their impact on the emergence and spread of antibiotic resistance remains unclear. Here we demonstrate that antidepressants, one of the most frequently prescribed drugs, can induce antibiotic resistance and persistence. Such effects are associated with increased reactive oxygen species, enhanced stress signature responses, and stimulation of efflux pump expression. Mathematical modeling also supported a role for antidepressants in the occurrence of antibiotic-resistant mutants and persister cells. Considering the high consumption of antidepressants (16,850 kg annually in the United States alone), our findings highlight the need to re-evaluate the antibiotic-like side effects of antidepressants.

An international team led by researchers from Nanyang Technological University, Singapore (NTU Singapore) has developed a universal connector to assemble stretchable devices simply and quickly, in a “Lego-like” manner.

Stretchable devices including soft robots and wearable health care devices are assembled using several different modules with different material characteristics—some soft, some rigid, and some encapsulated.

However, the commercial pastes (glue), currently used to connect the modules often either fail to transmit mechanical and electrical signals reliably when deformed or break easily.

The compound inside the mushroom could be used to treat Alzheimer’s.

An active compound found in an edible mushroom may just be able to improve nerve growth and enhance memory leading to treatments for debilitating diseases such as Alzheimer’s.

The mushroom can be found in North America, Europe, and Asia. In traditional Chinese medicine, it is used to boost the immune system and improve digestive health.

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Learn more about a new brain health study that suggests socioeconomic factors and mental health may be among the dementia risk factors we need to keep top of mind.

The World Health Organization hopes to test an experimental Marburg vaccine in Equatorial Guinea, which announced its first outbreak of the virus Monday.

Nine deaths have been confirmed, while 16 suspected patients are in quarantine. Health officials are also monitoring 15 asymptomatic close contacts of infected people.

No vaccine or antiviral treatment is approved to treat Marburg virus disease, which has an average death rate of around 50%, according to the WHO.

Scientists from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have removed a major roadblock to better understanding of mpox (formerly, monkeypox). They developed a mouse model of the disease and used it to demonstrate clear differences in virulence among the major genetic groups (clades) of mpox virus (MPXV).

The research, appearing in Proceedings of the National Academy of Science, was led by Bernard Moss, M.D., Ph.D., chief of the Genetic Engineering Section of NIAID’s Laboratory of Viral Diseases.

Historically, mpox, a disease resembling smallpox, was only occasionally transmitted from rodents to non-human primates or people, and was observed primarily in several African countries. Mpox rarely spread from person to person. That pattern changed in 2022 with an outbreak in which person-to-person mpox transmission occurred in more than 100 locations worldwide.

One question for Brad Ringeisen, a chemist and executive director of the Innovative Genomics Institute. Founded by Nobel Prize-winning biochemist Jennifer Doudna, it aims to bridge revolutionary gene-editing tool development to affordable and accessible solutions in human health and climate.

Will CRISPR cure cancer?

We’re always thinking about: What are those targets in the future? Cancer is one of those things. The biggest impact is going to be what’s called systemic delivery, or in vivo delivery. There’s been one example of this in the community right now—to treat a liver disease. Intellia Therapeutics, a biotech company, has shown that you can actually intravenously apply CRISPR-Cas9 treatment. (CRISPR is the guide RNA, the targeting molecule, and Cas9 is the cutting molecule that edits DNA.) It can go to the liver and target the liver cells, and make edits at a high enough efficacy to treat genetic liver disease. The problem is that the liver is the easiest. It’s like the garbage can of the body. Pretty much anything that you put into the body is ultimately going to find its way to the liver. So that’s absolutely the easiest tissue to deliver to. But trying to deliver to a solid tumor, or to the brain, is much more difficult.

Dr. Seol Seung-Kwon’s Smart 3D Printing Research Team at KERI and Professor Lim-Doo Jeong’s team at Ulsan National Institute of Science and Technology (UNIST) developed core technology for smart contact lenses that can implement augmented reality (AR)-based navigation, with a 3D printing process.

A smart contact lens is a product attached to the human eye like a normal lens that provides various information. Research on these lenses is currently focused mainly on diagnosing and treating health problems. Recently, Google and others are developing smart contact lenses for displays that can implement AR. Yet many obstacles to commercialization exist due to several technical challenges.

In implementing AR with smart contact lenses, electrochromic displays that can be driven with low power are necessary, and a “pure Prussian blue” color, with cost competitiveness and quick contrast and transition between colors, is attracting attention as the lens’ material. In the past, the color was coated on the substrate in the form of a film using the electric plating method, which limited the production of advanced displays that can express various information (letters, numbers, images).

Illustrated is the power of combined interference with different DNA damage response processes to combat cancer: Homologous recombination, which is selectively deficient in the tumour due to the BRCA defect, and base excision repair of single strand breaks, which is blocked by the administration of PARP inhibitors.

Client:
Dr. Rini de Crom.
Dr. Marja Miedema.
www.erasmusmc.nl, 2014

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