Lifeboat Foundation

The last-mile mobile health services provider, DocGo, has announced the delivery of its new all-electric, zero-emissions ambulance that eliminates the pollution of a standard gasoline ambulance.

The all–electric vehicle will be the first of its kind to be registered in the U.S. The new vehicle has been developed in partnership with Leader Emergency Vehicles in South El Monte, CA, and marks the first step towards “Zero Emission,” the company’s latest sustainability mission to have an all-electric fleet by 2032.

DocGo stated that its new vehicle produces 1/10th of the pollutants expelled by a standard gas-powered ambulance. In addition to being less harmful to the planet, the electric ambulance has the potential to lower patient transportation costs due to lower fuel costs and maintenance needs.

Synopsis: No sentient being in the evolutionary history of life has enjoyed good health as defined by the World Health Organization. The founding constitution of the World Health Organization commits the international community to a daringly ambitious conception of health: “a state of complete physical, mental and social wellbeing”. Health as so conceived is inconsistent with evolution via natural selection. Lifelong good health is inconsistent with a Darwinian genome. Indeed, the vision of the World Health Organization evokes the World Transhumanist Association. Transhumanists aspire to a civilization of superhappiness, superlongevity and superintelligence; but even an architecture of mind based on information-sensitive gradients of bliss cannot yield complete well-being. Post-Darwinian life will be sublime, but “complete” well-being is posthuman – more akin to Buddhist nirvana. So the aim of this talk is twofold. First, I shall explore the therapeutic interventions needed to underwrite the WHO conception of good health for everyone – or rather, a recognisable approximation of lifelong good health. What genes, allelic combinations and metabolic pathways must be targeted to deliver a biohappiness revolution: life based entirely on gradients of well-being? How can we devise a more civilized signalling system for human and nonhuman animal life than gradients of mental and physical pain? Secondly, how can genome reformists shift the Overton window of political discourse in favour of hedonic uplift? How can prospective parents worldwide – and the World Health Organization – be encouraged to embrace genome reform? For only germline engineering can fix the problem of suffering and create a happy biosphere for all sentient beings.

https://www.scifuture.org/the-end-of-suffering-genome-reform…id-pearce/

Bullying can make kid’s lives a misery and cause lifelong health problems – but scientists are discovering powerful ways to fight it.

Researchers at NTNU have managed to restore muscle function in older mice with muscle loss using advanced gene therapy. The hope is that this method might eventually be used on humans to prevent severe loss of muscle mass.

“Gene therapy is the most effective method to be able to give these people the same health benefits you normally get with physical exercise,” says Moreira, who has been involved in the new research. He is part of the Cardiac Exercise Research Group (CERG).

NIH-funded study identifies brain cells that form boundaries between discrete events.

Researchers have identified two types of cells in our brains that are involved in organizing discrete memories based on when they occurred. This finding improves our understanding of how the human brain forms memories and could have implications in memory disorders such as Alzheimer’s disease. The study was supported by the National Institutes of Health’s Brain Research Through Advancing Innovative Neurotechnologies (BRAIN) Initiative and published in Nature Neuroscience.

“This work is transformative in how the researchers studied the way the human brain thinks,” said Jim Gnadt, Ph.D., program director at the National Institute of Neurological Disorders and Stroke and the NIH BRAIN Initiative. “It brings to human neuroscience an approach used previously in non-human primates and rodents by recording directly from neurons that are generating thoughts.”

Drugs are polluting rivers and adding to the resistance crisis as well as affecting riverine ecosystems.

Pharmaceutical pollution in the world’s rivers is threatening environmental and human health and the attainment of UN goals on water quality, with developing countries the worst affected, a global study warns.

Active pharmaceutical ingredients (APIs) could be contributing to antimicrobial resistance in microorganisms, and may have unknown long-term effects on human health, as well as harming aquatic life, according to the report published in Proceedings of the National Academy of Sciences.

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The CRISPR gene-editing system is a powerful tool that could revolutionize medicine and other sciences, but unfortunately it has a tendency to make edits to the wrong sections of DNA. Now, researchers at the University of Texas at Austin have identified a previously unknown structure of the protein that drives these mistakes, and tweaked it to reduce the likelihood of off-target mutations by 4,000 times.

CRISPR tools use certain proteins, most often Cas9, to make precise edits to specific DNA sequences in living cells. This can involve cutting out problematic genes, such as those that cause disease, and/or slotting in beneficial ones. The problem is that sometimes the tool can make changes to the wrong parts, potentially triggering a range of other health issues.

And in the new study, the UT researchers discovered how some of these errors can happen. Usually, the Cas9 protein is hunting for a specific sequence of 20 letters in the DNA code, but if it finds one where 18 out of 20 match its target, it might make its edit anyway. To find out why this occurs, the team used cryo-electron microscopy to observe what Cas9 is doing when it interacts with a mismatched sequence.

It’s easy to see why: as shockingly powerful mini-processors, neurons and their connections—together dubbed the connectome—hold the secret to highly efficient and flexible computation. Nestled inside the brain’s wiring diagrams are the keys to consciousness, memories, and emotion. To connectomics, mapping the brain isn’t just an academic exercise to better understand ourselves—it could lead to more efficient AI that thinks like us.

But often ignored are the brain’s supporting characters: astrocytes—brain cells shaped like stars—and microglia, specialized immune cells. Previously considered “wallflowers,” these cells nurture neurons and fine-tune their connections, ultimately shaping the connectome. Without this long-forgotten half, the brain wouldn’t be the computing wizard we strive to imitate with machines.

In a stunning new brain map published in Cell, these cells are finally having their time in the spotlight. Led by Dr. H. Sebastian Seung at Princeton University, the original prophet of the connectome, the map captures a tiny chunk of the mouse’s visual cortex, less than 1,000 times smaller than a pea. Yet jam-packed inside the map aren’t just neurons; in a technical tour de force, the team mapped all brain cells, their connections, blood vessels, and even the compartments inside cells that house DNA and produce energy.

Could 2 B vitamins help those suffering with Huntington’s Disease?

T he Huntington’s disease (HD) community has recently experienced setbacks, but a new research report may reignite hope, from an unexpected source: the vitamin thiamine (B1), with help from biotin (B7). The investigators, from several institutions in Spain and UCLA, write in Science Translational Medicine, “Together, these results demonstrate a thiamine deficiency in HD brain and suggest that individuals with HD might benefit from thiamine and/or biotin supplementation therapy.”

Health care providers may suggest certain supplements for HD patients, based perhaps on a deficiency (vitamins C, B12, E) in the blood, or for general health. But the new findings are different. The researchers didn’t set out to detect a vitamin deficiency, but instead probed the messaging within cells in the HD brain, which led them to a biochemical juncture that revealed the thiamine/biotin connection.

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