Lifeboat Foundation

The results of a human study carried out by an international research team have provided valuable new insights into the activity of the brain’s noradrenaline (NA) system, which has been a longtime target for medications to treat attention-deficit/hyperactivity disorder, depression, and anxiety. The study employed what the researchers claim is a groundbreaking methodology, developed to record real-time chemical activity from standard clinical electrodes implanted into the brain routinely for epilepsy monitoring.

The results offer up new insights into brain chemistry, which could have implications for a wide array of medical conditions, and also demonstrate use of the new strategy for acquiring data from the living human brain.

“Our group is describing the first ‘fast’ neurochemistry recorded by voltammetry from conscious humans,” said Read Montague, PhD, the VTC Vernon Mountcastle research professor at Virginia Tech, and director of the Center for Human Neuroscience Research and the Human Neuroimaging Laboratory of the Fralin Biomedical Research Institute at VTC. “This is a big step forward and the methodological approach was implemented completely in humans – after more than 11 years of extensive development.” Montague is senior, and co-corresponding author of the researchers’ published paper in Current Biology, which is titled “Noradrenaline tracks emotional modulation of attention in human amygdala.” In their paper the authors concluded, “By showing that neuromodulator estimates can be obtained from depth electrodes already in standard clinical use in the conscious human brain, our study opens the door to a new area of research on the neuromodulatory basis of human health and disease.”

An international research team led by scientists at the Hudson Institute of Medical Research has found a way to determine which species of gut microbiota are important in certain diseases, and how they interact with other microorganisms to create a healthy microbiome.

The team developed a computational metabolite exchange scoring system to identify microbial cross feeding relationships—the use of metabolites produced by one microorganism as an essential nutrients by another—and how these may be altered in disease. The researchers suggest that understanding such relationships could point to therapeutic approaches for a range of disorders including inflammatory bowel disease, infections, autoimmune diseases and cancer.

“There are roughly 1,000 different bacterial species in a healthy gut—it’s a microscopic multicultural community with over a trillion individual members,” said research lead Samuel Forster, PhD. “Bacteria in our microbiomes exist as communities that rely on each other to produce and share key nutrients between them … We have developed a new computational way to understand these dependencies and their role in shaping our microbiome. This new method unlocks our understanding of the gut microbiome and provides a foundation for new treatment options that selectively remodel microbial communities.”

The more diverse species in your gut, the better it is for your health. Now an international team led by the Hudson Institute of Medical Research has found a way to determine which species are important and how they interact to create a healthy microbiome.

Understanding these relationships opens the door to a new world of medical opportunities for conditions from inflammatory bowel disease to infections, autoimmune diseases and cancers.

Associate Professor Samuel Forster and his team at Hudson Institute of Medical Research, working with collaborators from the Institute for Systems Biology in the U.S. and local collaborators at Monash University and Monash Health, have spent years studying the gut microbiome and working out which species perform which functions.

Radiotherapy (also called radiation therapy), a commonly used cancer treatment that uses high-energy radiation, can effectively eliminate or shrink various types of tumors. While radiotherapy benefits many cancer patients, the associated side effects can hinder cancer survivors’ quality of life and overall health.

When a patient receives radiation treatments, the radiation damages the DNA. If the DNA damage becomes severe enough, the cancer cell will not recover and will stop dividing and die. Unfortunately, the exact mechanisms by which radiation elicits cancer cell death can cause similar damage in nearby healthy cells, leading to significant toxicities in some cases.

Many malignancies that develop in the pelvic region, including urinary and rectal cancers, are susceptible to pelvic radiotherapy. Some patients receiving pelvic radiotherapy develop debilitating bowel symptoms, including intestinal inflammation. Doctors do not fully understand these clinical challenges despite the common occurrence of bowel symptoms following pelvic radiotherapy. A better understanding of the link between radiation and bowel damage could help doctors manage cancer treatment more optimally, enhancing survivorship.

Congress is currently debating the FAA’s long-term reauthorization, which might have an impact on the ongoing use of leaded aviation fuel at smaller airports.

Serjio74/iStock.

Since 1980, the US has had a stunning 99 percent reduction in airborne lead levels as a result of EPA regulations. However, Leaded gas is still used in the aviation industry, according to a report published by EPA on Wednesday.

Continue reading “Health crisis: 220,000 planes still use lead fuel, warns US agency” »

Influenza viruses are believed to have sparked at least 14 human pandemics in the past 500 years; the most devastating of which began in 1918. Yet, despite intense study and considerable advances in public health, virus surveillance and virology, there is no simple answer to this pressing question: when and how will the next flu pandemic arise?

NIAID scientists including Jeffery K. Taubenberger, M.D., Ph.D., consider the many potential pathways to future influenza pandemics in a new viewpoints essay in Science Translational Medicine. There are no hard and fast ‘rules’ specifying, for example, what characteristics a given avian influenza virus must possess to allow it to efficiently infect… More.

Influenza pandemics have emerged for centuries but still cannot be accurately predicted.

Breast changes are very common, and most breast changes are not cancer. Our health guide for women explains:

A breast lump may be benign or a symptom of breast cancer. Learn about follow-up after an abnormal mammogram. See pictures of breast cancer, cysts, and calcifications. Find out symptoms for benign breast conditions, precancers, and DCIS.

It’s been a month since a Maryland man became the second person to receive a transplanted heart from a pig — and hospital video released Friday shows he’s working hard to recover.

Lawrence Faucette was dying from heart failure and ineligible for a traditional heart transplant when doctors at the University of Maryland School of Medicine offered the highly experimental surgery.

In the first glimpse of Faucette provided since the Sept. 20 transplant, hospital video shows physical therapist Chris Wells urging him to push through a pedaling exercise to regain his strength.

Autonomous shopping carts that follow grocery store customers and robots that pick ripe cucumbers faster than humans may grab headlines, but the most compelling applications of AI and ML technology are behind the scenes. Increasingly, organizations are finding substantial efficiency gains by applying AI-and ML-powered tools to back-office procedures such as document processing, data entry, employee onboarding, and workflow automation.

The power of automation to augment productivity in the back office has been clear for decades, but the recent emergence of advanced AI and ML tools offers a step change in what automation can accomplish, including in highly regulated industries such as health care.