Lifeboat Foundation

Part 1: the future of medicine: nanobots part 2: a new era in mental health: nanobots part 3: the healing power of nanobots part 4: the genetic and data-connected revolution: nanobots part 5: the end of plastic surgery: nanobots part 6: the fertility revolution: nanobots part 7: the job-specific human: nanobots part 8: the end of education as we know it: nanobots part 9: the rise of programmable matter: nanobots part 10: the next generation of humans: nanobots.

Nanotechnology is a rapidly evolving field with the potential to revolutionize medicine in the future. One of the most promising applications of nanotechnology is the use of nanobots in medicine. Nanobots are microscopic robots that can be programmed to perform specialized activities such as disease diagnosis and treatment. They can be used to diagnose and treat a wide range of conditions, including mental illnesses such as depression and anxiety, as well as physical injuries and illnesses.

One of the most interesting potential applications of nanobots in medicine is the treatment of mental illnesses. Mental illnesses are among the most common and devastating diseases of our time. They can be programmed to constantly map the brain and correct faults as they develop. Alzheimer’s disease may theoretically be treated if a person was implanted with nanobots at birth.

Researchers report a new, highly unusual, structured-light family of 3D topological solitons, the photonic hopfions, where the topological textures and topological numbers can be freely and independently tuned.

We can frequently find in our daily lives a localized wave structure that maintains its shape upon propagation—picture a smoke ring flying in the air. Similar stable structures have been studied in various research fields and can be found in magnets, nuclear systems, and particle physics. In contrast to a ring of smoke, they can be made resilient to perturbations. This is known in mathematics and physics as topological protection.

A typical example is the nanoscale hurricane-like texture of a magnetic field in magnetic thin films, behaving as particles—that is, not changing their shape—called skyrmions. Similar doughnut-shaped (or toroidal) patterns in 3D space, visualizing complex spatial distributions of various properties of a wave, are called hopfions. Achieving such structures with light waves is very elusive.

Scientists from UNSW Sydney have demonstrated a novel technique for creating tiny 3D materials that could eventually make fuel cells like hydrogen batteries cheaper and more sustainable.

In the study published in Science Advances (“Synthesis of hierarchical metal nanostructures with high electrocatalytic surface areas”), researchers from the School of Chemistry at UNSW Science show it’s possible to sequentially ‘grow’ interconnected hierarchical structures in 3D at the nanoscale which have unique chemical and physical properties to support energy conversion reactions.

In chemistry, hierarchical structures are configurations of units like molecules within an organisation of other units that themselves may be ordered. Similar phenomena can be seen in the natural world, like in flower petals and tree branches. But where these structures have extraordinary potential is at a level beyond the visibility of the human eye – at the nanoscale.

Novel drugs, such as vaccines against COVID-19, among others, are based on drug transport using nanoparticles. Whether this drug transport is negatively influenced by an accumulation of blood proteins on the nanoparticle’s surface was not clarified for a long time.

Scientists at the Max Planck Institute for Polymer Research have now followed the path of such a particle into a cell using a combination of several microscopy methods. They were able to observe a cell-internal process that effectively separates blood components and nanoparticles.

Nanoparticles are a current field of research and it is impossible to imagine modern medicine without them. They serve as microscopic drug capsules that are less than a thousandth of a millimeter in diameter. Among other things, they are used in current vaccines against COVID-19 to effectively deliver active ingredients to where they are actually needed. In most cases, the capsules dock onto cells, are enveloped by them, and are absorbed into them. Inside the cell, chemical processes can then open the capsules, releasing the active ingredient.

We can frequently find in our daily lives a localized wave structure that maintains its shape upon propagation—picture a smoke ring flying in the air. Similar stable structures have been studied in various research fields and can be found in magnets, nuclear systems, and particle physics. In contrast to a ring of smoke, they can be made resilient to perturbations. This is known in mathematics and physics as topological protection.

A typical example is the nanoscale hurricane-like texture of a magnetic field in magnetic thin films, behaving as particles—that is, not changing their shape—called skyrmions. Similar doughnut-shaped (or toroidal) patterns in 3D space, visualizing complex spatial distributions of various properties of a wave, are called hopfions. Achieving such structures with light waves is very elusive.

Recent studies of structured light revealed strong spatial variations of polarization, phase, and amplitude, which enable the understanding of—and open up opportunities for designing—topologically stable optical structures behaving like particles. Such quasiparticles of light with control of diversified topological properties may have great potential, for example as next-generation information carriers for ultra-large-capacity optical information transfer, as well as in quantum technologies.

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Summary: Researchers have developed a new family of nano-scale capsules capable of carrying CRISPR gene editing tools to different organs of the body before harmlessly dissolving. The capsules were able to enter the brains of mice and successfully edit a gene associated with Alzheimer’s disease.

Source: University of Wisconsin-Madison.

Gene therapies have the potential to treat neurological disorders like Alzheimer’s and Parkinson’s diseases, but they face a common barrier — the blood-brain barrier.

Gene therapies have the potential to treat neurological disorders like Alzheimer’s and Parkinson’s diseases, but they face a common barrier—the blood-brain barrier. Now, researchers at the University of Wisconsin-Madison have developed a way to move therapies across the brain’s protective membrane to deliver brain-wide therapy with a range of biological medications and treatments.

“There is no cure yet for many devastating brain disorders,” says Shaoqin “Sarah” Gong, UW-Madison professor of ophthalmology and visual sciences and biomedical engineering and researcher at the Wisconsin Institute for Discovery. “Innovative brain-targeted delivery strategies may change that by enabling noninvasive, safe and efficient delivery of CRISPR genome editors that could, in turn, lead to genome-editing therapies for these diseases.”

CRISPR is a molecular toolkit for editing genes (for example, to correct mutations that may cause disease), but the toolkit is only useful if it can get through security to the job site. The blood-brain barrier is a membrane that selectively controls access to the brain, screening out toxins and pathogens that may be present in the bloodstream. Unfortunately, the barrier bars some beneficial treatments, like certain vaccines and gene therapy packages, from reaching their targets because in lumps them in with hostile invaders.

University of California, Berkeley, chemists have created a new type of material from millions of identical, interlocking molecules, that for the first time allows the synthesis of extensive 2D or 3D structures that are flexible, strong and resilient, like the chain mail that protected medieval knights.

The material, called an infinite catenane, can be synthesized in a single chemical step.

Continue reading “New ‘chain mail’ material of interlocking molecules is tough, flexible and easy to make” »