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Researchers at FutureNeuro, the SFI Research Centre for Translational Brain Science, and RCSI University of Medicine and Health Sciences, in collaboration with international partners, have developed a revolutionary technique to profile gene activity in the living human brain.

This innovative approach, published in JCI Insight, opens new avenues for understanding and treating neurological conditions like epilepsy.

Studying gene activity in the brain without requiring invasive tissue samples from surgery or post-mortem donation has been a long-standing challenge in neuroscience. By analyzing molecular traces – specifically RNA and DNA – collected from electrodes implanted in the brains of patients with epilepsy and linking these with electrical recordings from the brain, the researchers were able to take a ‘snapshot’ of gene activity in the living brain.

New experiments reveal how the brain chooses which memories to save and add credence to advice about the importance of rest.

Memory, a fundamental aspect of human cognition and consciousness, is multifaceted and extends beyond traditional conceptualizations of mental recall. This review article explores memory through various lenses, including brain-based, body-based, and cellular mechanisms. At its core, memory involves the encoding, storage, and retrieval of information. Advances in neuroscience reveal that synaptic changes and molecular modifications, particularly in the hippocampus, are crucial for memory consolidation. Additionally, body memory, or somatic memory, highlights how sensory experiences and traumatic events are stored and influence behavior, underscoring the role of implicit memory. Multiple studies have demonstrated that memories can be encoded and stored in cells. Evidence suggests that these memories can then be transferred between individuals through organ transplantation.

Some researchers propose that advancing AI to the next level will require an internal architecture that more closely mirrors the human mind. Rufin VanRullen joins Brian Greene to discuss early results from one such approach, based on the Global Workspace Theory of consciousness.

This program is part of the Big Ideas series, supported by the John Templeton Foundation.

Continue reading “Can Models of Human Consciousness Enhance AI Capabilities?” »

A new study by the University of Reading on human brain evolution has found that modern humans, Neanderthals, and other recent relatives evolved larger brains much more rapidly than earlier species. This challenges previous ideas, suggesting that brain size increased gradually within each ancient human species, rather than through sudden leaps between species.

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Discover how NREM sleep enhances cognitive performance and the potential to mimic its benefits through brain stimulation.

In the study of temporal mechanics, we have to venture beyond the confines of traditional objective science to incorporate the profound role of consciousness in shaping our understanding of time. The evidence and theories discussed throughout my upcoming paper (to be released as a Kindle eBook) suggest that the flow of time is not simply a physical phenomenon dictated by the laws of thermodynamics or the spacetime continuum, but rather a deeply psychological one, intertwined with consciousness itself. Time, as we experience it, emerges from our awareness of ongoing change—a continuous psychological construct that weaves our perceptions into a coherent narrative of past, present, and future.

The implications of this perspective are far-reaching. If the flow of time is indeed a function of consciousness, then time cannot be fully understood without accounting for the observer—the conscious entity whose perception of change gives rise to the experience of time. This challenges the classical notion of time as a separate, objective entity and places consciousness as a central player in the multidimensional matrix of reality.

Emotional body odors may have the potential to enhance the anxiety-reducing effects of mindfulness. This is shown by a pilot study published in the Journal of Affective Disorders, co-authored by researchers from Karolinska Institutet.

Body odors can serve as a means of social communication. Body odors, such as sweat, contain a cocktail of chemical processes (so-called chemosignals), which in turn are influenced by a person’s emotional state. Studies indicate that individuals exposed to chemosignals from a person in a particular emotional state, such as fear or happiness, exhibit a certain replication of this state. This replication occurs unconsciously and has most often been observed through different physiological tests.

As most studies in this area have involved healthy subjects, the overall goal of this project was to study the potential benefit of chemosignals for individuals with psychiatric symptoms. The purpose of this study was therefore to investigate whether emotional body odors can enhance the benefits of a mindfulness-based intervention for individuals with social anxiety or depression.

Nanotechnology is poised to transform neurological disorder treatments by overcoming the blood-brain barrier, enabling effective medication delivery for conditions like dementia and Alzheimer’s. This innovative approach also shows promise in dermatology and cancer treatment, enhancing drug absorption and targeting, while minimizing side effects. Experts at AIIMS highlighted ongoing research and potential breakthroughs expected in the next few years.