Lifeboat Foundation

Low mental health associated with worse outcomes after total hip arthroplasty suggests a new study published in the Archives of Orthopaedic and Trauma Surgery.

Poor mental health is difficult to recognize and as a result, its association with recovery from total joint arthroplasty is difficult to assess. The purpose of this study was to investigate the relationship between overall mental health scores and outcomes in the early postoperative period following unilateral total hip arthroplasty (THA). This is a retrospective review of prospectively collected data involving 142 patients who underwent primary unilateral THA. Independent variables included patient demographics and preoperative Patient-Reported Outcomes Measurement Information System (PROMIS), Global Physical Health (GPH) and Global Mental Health (GMH) and Hip Disability and Osteoarthritis Outcome Score, Joint Replacement (HOOS JR) scores as well as diagnoses of depression or anxiety.

When you get in the car to see your significant other for dinner, your brain’s reward center is likely flooded with dopamine, a hormone also associated with cravings for sugar, nicotine, and cocaine. This rush of dopamine motivates you to navigate through traffic to maintain that special connection. However, if the dinner is with just a work colleague, this intense flood of dopamine may be reduced to a mere trickle, according to recent research conducted by neuroscientists at the University of Colorado Boulder.

“What we have found, essentially, is a biological signature of desire that helps us explain why we want to be with some people more than other people,” said senior author Zoe Donaldson, associate professor of behavioral neuroscience at CU Boulder.

SynapShot, developed by an international research team, marks a major advancement in neuroscience by enabling real-time, live observation of synaptic changes in the brain.

The human brain contains approximately 86 billion neurons and 600 trillion synapses that exchange signals between the neurons to help us control the various functions of the brain including cognition, emotion, and memory. Interestingly, the number of synapses decrease with age or as a result of diseases like Alzheimer’s, and research on synapses thus attracts a lot of attention. However, limitations have existed in observing the dynamics of synapse structures in real-time.

We’re reading more than ever before – but much of it is on screens rather than physical books. Is it changing the way our brains work? Reading books has so many physical, emotional and economic benefits — here’s why how we read might be more important than what or how much we read.

Video by Daniel Nils Roberts.

Continue reading “What does reading on screens do to our brains? | BBC Ideas” »

Autism is characterized by impairments in social communication and interaction and restricted and repetitive behaviors. In this video, I discuss the neuroscience of autism along with potential factors and mechanisms involved in the development of autism.

TRANSCRIPT:

Continue reading “2-Minute Neuroscience: Autism” »

It has been known for more than century that increases in neural activity in the brain drive changes in local blood flow, known as neurovascular coupling. The colloquial explanation for these increases in blood flow (referred to as functional hyperemia) in the brain is that they serve to supply the needs of metabolically active neurons. However, there is an large body of evidence that is inconsistent with this idea. In most cases, baseline blood flow is adequate to supply even elevated neural activity. Neurovascular coupling is irregular, absent, or inverted in many brain regions, behavioral states, and conditions. Increases in respiration can generate increases in brain oxygenation independently of flow changes. Simulations have shown that areas with low blood flow are inescapable and cannot be removed by functional hyperemia given the architecture of the cerebral vasculature. What physiological purpose might neurovascular coupling serve? Here, we discuss potential alternative functions of neurovascular coupling. It may serve supply oxygen for neuromodulator synthesis, to regulate cerebral temperature, signal to neurons, stabilize and optimize the cerebral vascular structure, deal with the non-Newtonian nature of blood, or drive the production and circulation of cerebrospinal fluid around and through the brain via arterial dilations. Understanding the ‘why’ of neurovascular coupling is an important goal that give insight into the pathologies caused by cerebrovascular disfunction.

Like all energy demanding organs, the brain is highly vascularized. When presented with a sensory stimulus or cognitive task, increases in neural activity in many brain regions are accompanied by local dilation of arterioles and other microvessels, increasing local blood flow, volume and oxygenation. The increase in blood flow in response to increased neural activity (known as functional hyperemia) is controlled by a multitude of different signaling pathways via neurovascular coupling (reviewed in [1,2]). These vascular changes can be monitored non-invasively in humans and other species, with techniques (like BOLD fMRI) that are cornerstones in modern neuroscience [3,4]. Chronic disruptions of neurovascular coupling have adverse health effects on the brain. Stress affects neurovascular coupling [5,6], and many neurodegenerative diseases are marked by vascular dysfunction [7].

The potential applications of Neuralink are vast and could potentially change humanity in many ways. While there are potential drawbacks, the potential benefits make the development of this technology an exciting prospect.

In 1,868, Jean-Martin Charcot, a neurologist at the Hôpital de Salpétrière in France, first coined the disease “la sclérose en plaques,” which means multiple sclerosis (MS) — to distinguish it from another type of movement disorder later known as Parkinson’s disease.

Though described in 1,868, the cause of MS puzzled scientists for more than a century. This is until a 2022 breakthrough study finally enlightens us that the cause is, oddly, the seemingly innocent Epstein-Barr virus (EBV), a common childhood virus that causes typical fever and sore throat.

Let’s see how one study single-handedly proves what we thought couldn’t be proved; how one study truly deserves to be called a breakthrough; and how thorough and near-perfect science is done.

The various identities of cells, whether they are in the brain, heart, kidney, or any other tissue, are defined by the genes they expressed. In basic terms, the genes that are active in a cell are transcribed into RNA molecules that are then translated into proteins using tRNA molecules. In the genetic code, three base pair sequences of DNA, or codons, represent amino acids. These amino acids are moved into place by tRNA molecules, which have matching anticodons, to make proteins. There is redundancy in the genetic code as well, in which one amino acid can often be encoded by a few different codons.

Protein production varies considerably in different cells, and this is especially notable in cells that generate antibodies. These cells often have to spring into action and shift into high gear to generate many infection-fighting antibodies quickly. These antibody producers are B cells, and they often make significant metabolic adaptations when they’re needed.