Lifeboat Foundation

Researchers have used a machine learning model to identify three compounds that could combat aging. They say their approach could be an effective way of identifying new drugs, especially for complex diseases.

Cell division is necessary for our body to grow and for tissues to renew themselves. Cellular senescence describes the phenomenon where cells permanently stop dividing but remain in the body, causing tissue damage and aging across body organs and systems.

Ordinarily, senescent cells are cleared from the body by our immune system. But, as we age, our immune system is less effective at clearing out these cells and their number increases. An increase in senescent cells has been associated with diseases such as cancer, Alzheimer’s disease and the hallmarks of aging such as worsening eyesight and reduced mobility. Given the potentially deleterious effects on the body, there has been a push to develop effective senolytics, compounds that clear out senescent cells.

Researchers from North Carolina State University have identified a microRNA (miRNA) that could promote hair regeneration. This miRNA – miR-218-5p – plays an important role in regulating the pathway involved in follicle regeneration, and could be a candidate for future drug development.

Hair growth depends on the health of dermal papillae (DP) cells, which regulate the hair follicle growth cycle. Current treatments for hair loss can be costly and ineffective, ranging from invasive surgery to chemical treatments that don’t produce the desired result. Recent hair loss research indicates that hair follicles don’t disappear where balding occurs, they just shrink. If DP cells could be replenished at those sites, the thinking goes, then the follicles might recover.

A research team led by Ke Cheng, Randall B. Terry, Jr. Distinguished Professor in Regenerative Medicine at NC State’s College of Veterinary Medicine and professor in the NC State/UNC Joint Department of Biomedical Engineering, cultured DP cells both alone (2D) and in a 3D spheroid environment. A spheroid is a three-dimensional cellular structure that effectively recreates a cell’s natural microenvironment.

Circa 2020

Imagine a dressing that releases antibiotics on demand and absorbs excessive wound exudate at the same time. Researchers at Eindhoven University of Technology hope to achieve just that, by developing a smart coating that actively releases and absorbs multiple fluids, triggered by a radio signal. This material is not only beneficial for the health care industry, it is also very promising in the field of robotics or even virtual reality.

Continue reading “Artificial skin heals wounds and makes robots sweat” »

Controlling chemical reactions to generate new products is one of the biggest challenges in chemistry. Developments in this area impact industry, for example, by reducing the waste generated in the manufacture of construction materials or by improving the production of catalysts to accelerate chemical reactions.

For this reason, in the field of polariton chemistry—which uses tools of chemistry and quantum optics—in the last 10 years different laboratories around the world have developed experiments in optical cavities to manipulate the chemical reactivity of molecules at room temperature, using electromagnetic fields. Some have succeeded in modifying chemical reactions products in organic compounds, but to date, and without relevant advances in the last two years, no research team has been able to come up with a general physical mechanism to describe the phenomenon and to reproduce it to obtain the same measurements in a consistent manner.

Now a team of researchers from Universidad de Santiago (Chile), part of the Millennium Institute for Research in Optics (MIRO), led by principal investigator Felipe Herrera, and the laboratory of the chemistry division of the US Naval Research Laboratory, (United States), led by researcher Blake Simpkins, for the first time report the manipulation of the formation rate of urethane molecules in a solution contained inside an infrared cavity.

During photosynthesis, a symphony of chemicals transforms light into the energy required for plant, algal, and some bacterial life. Scientists now know that this remarkable reaction requires the smallest possible amount of light – just one single photon – to begin.

A US team of researchers in quantum optics and biology showed that a lone photon can start photosynthesis in the purple bacterium Rhodobacter sphaeroides, and they are confident it works in plants and algae since all photosynthetic organisms share an evolutionary ancestor and similar processes.

The team says their findings bolster our knowledge of photosynthesis and will lead to a better understanding of the intersection of quantum physics in a wide range of complex biological, chemical, and physical systems, including renewable fuels.

In a collaboration with Groningen University, Professor Jørgen Kjems and his research group at Aarhus University have achieved a remarkable breakthrough in developing tiny nano-sized pores that can contribute to better possibilities for, among other things, detecting diseases at an earlier stage.

Their work, recently published in the journal ACS Nano, shows a new innovative method for finding specific proteins in complex biological fluids, such as blood, without having to label the proteins chemically. The research is an important milestone in nanopore technology, and could revolutionize medical diagnostics.

Nanopores are tiny channels formed in materials, that can be used as sensors. The researchers, led by Jørgen Kjems and Giovanni Maglia (Groningen Univ.), have taken this a step further by developing a special type of nanopore called ClyA with scanner molecules, called nanobodies, attached to it.

Artificial intelligence (AI) and its latest contribution to the development of anti-aging drugs has paved the way for breakthrough discoveries in modern medicine.

Researchers, using AI technology, have successfully identified three chemicals that specifically target malfunctioning cells, believed to be associated with certain cancers and Alzheimer’s disease.

A group of scientists from the University of Edinburgh developed an AI algorithm to screen a collection of over 4,300 chemical compounds.

In situ bioprinting, which involves 3D printing biocompatible structures and tissues directly within the body, has seen steady progress over the past few years. In a recent study, a team of researchers developed a handheld bioprinter that addresses key limitations of previous designs, i.e., the ability to print multiple materials and control the physicochemical properties of printed tissues. This device will pave the way for a wide variety of applications in regenerative medicine, drug development and testing, and custom orthotics and prosthetics.

The emergence of regenerative medicine has resulted in substantial improvements in the lives of patients worldwide through the replacement, repair, or regeneration of damaged tissues and organs. It is a promising solution to challenges such as the lack of organ donors or transplantation-associated risks. One of the major advancements in regenerative medicine is on-site (or “in situ”) bioprinting, an extension of 3D printing technology, which is used to directly synthesize tissues and organs within the human body. It shows great potential in facilitating the repair and regeneration of defective tissues and organs.

Although significant progress has been made in this field, currently used in situ bioprinting technologies are not devoid of limitations. For instance, certain devices are only compatible with specific types of bioink, while others can only create small patches of tissue at a time. Moreover, their designs are usually complex, making them unaffordable and restricting their applications.

How can the mindless microscopic particles that compose our brains ‘experience’ the setting sun, the Mozart Requiem, and romantic love? How can sparks of brain electricity and flows of brain chemicals literally be these felt experiences or be ‘about’ things that have external meaning? How can consciousness be explained?

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Continue reading “Keith Ward — Why is Consciousness so Mysterious?” »