This study demonstrates that AI can be incredibly effective in helping us identify new drug candidates – particularly at early stages of drug discovery and for diseases with complex biology or few known molecular targets.
A machine learning model has been trained to recognise the key features of chemicals with senolytic activity. It recently found three chemicals able to remove senescent cells without damaging healthy cells.
Molecular structure of oleandrin. Credit: Mplanine, CC BY-SA 4.0, via Wikimedia Commons.
For many years, the fields of physics and chemistry have held the belief that the properties of solid materials are fundamentally determined by the atoms and molecules they consist of. For instance, the crystalline nature of salt is credited to the ionic bond formed between sodium and chloride ions. Similarly, metals such as iron or copper owe their robustness to the metallic bonds between their respective atoms, and the elasticity of rubbers stems from the flexible bonds in the polymers that form them. This principle also applies to substances like fungi, bacteria, and wood.
Or so the story goes.
A new paper recently published in Nature upends that paradigm, and argues that the character of many biological materials is actually created by the water that permeates these materials. Water gives rise to a solid and goes on to define the properties of that solid, all the while maintaining its liquid characteristics.
ALBUQUERQUE, N.M. — In people with epilepsy, seizure-alert dogs can smell small changes in body chemistry and warn of an impending seizure an hour or more before it occurs. Inspired by this feat of nature, a team of researchers has sniffed out a way to replicate the ability with technology.
Rocks and minerals contribute essential raw materials for any civilization, and in a technological society minerals (and the rare elements they contain) are especially sought after. In the past, most discoveries of mineral deposits have resulted from perseverance and luck.
In the last 200 years scientists realized that minerals are not distributed randomly. Many of the over 5,000 different minerals occurring on Earth exist in a so-called paragenesis. A paragenesis is a mineral assemblage formed under specific physico-chemical rules, like a certain chemical composition of the host rock or when the right conditions — like temperature and pressure — are met.
A machine learning model can predict the locations of minerals on Earth — and potentially other planets — by taking advantage of patterns in mineral associations.
It has almost been 20 years since the establishment of the field of two-dimensional (2D) materials with the discovery of unique properties of graphene, a single, atomically thin layer of graphite. The significance of graphene and its one-of-a-kind properties was recognized as early as 2010 when the Nobel prize in physics was awarded to A. Geim and K. Novoselov for their work on graphene. However, graphene has been around for a while, though researchers simply did not realize what it was, or how special it is (often, it was considered annoying dirt on nice, clean surfaces of metals REF). Some scientists even dismissed the idea that 2D materials could exist in our three-dimensional world.
Today, things are different. 2D materials are one of the most exciting and fascinating subjects of study for researchers from many disciplines, including physics, chemistry and engineering. 2D materials are not only interesting from a scientific point of view, they are also extremely interesting for industrial and technological applications, such as touchscreens and batteries.
We are also getting very good at discovering and preparing new 2D materials, and the list of known and available 2D materials is rapidly expanding. The 2D materials family is getting very large and graphene is not alone anymore. Instead, it now has a lot of 2D relatives with different properties and vastly diverse applications, predicted or already achieved.
According to a news release from the Vienna University of Technology (TU Wien), oxygen-ion batteries don’t have the same aging issue that lithium batteries face, which means they can maintain effectiveness for an incredibly long period.
They can also be manufactured using incombustible materials and don’t require the same rare elements as lithium batteries, which means they won’t have nearly as substantial of an environmental footprint and won’t spontaneously explode if mishandled.
“In many batteries, you have the problem that at some point the charge carriers can no longer move,” said Alexander Schmid of TU Wien’s Institute for Chemical Technologies. “Then they can no longer be used to generate electricity, the capacity of the battery decreases. After many charging cycles, that can become a serious problem.”
A team of researchers successfully constructed nanofiltration membranes with superior quality using the mussel-inspired deposition methods. Such was achieved via a two-part approach to fabricate the thin-film composite (TFC) nanofiltration membranes. Firstly, the substrate surface was coated through fast and novel deposition to form a dense, robust, and functional selective layer. Then, the structure controllability of the selective layer was enhanced by optimizing the interfacial polymerization (IP) process. As a result, the properties of nanofiltration membranes produced are with high durability and added functionality. When put into a bigger perspective, these high-performance TFC nanofiltration membranes are potential solutions to a number of fields, including water softening, wastewater treatment, and pharmaceutical purification. Hence, there is a need to further explore and expand the application in an industrial scale instead of being bound within the walls of the laboratories.
Membrane-based technologies, especially enhanced nanofiltration systems, have been highly explored due to their myriad of distinct properties, primarily for their high efficiency, mild operation, and strong adaptability. Among these, the TFC nanofiltration membranes are favoured for their smaller molecular weight cutoff, and narrower pore size distribution which lead to higher divalent and multivalent ion rejection ability. Moreover, these membranes show better designability owing to their thin selective layer make-up and porous support with different chemical compositions. However, the interfacial polymerization (IP) rate of reaction is known to affect the permeability and selectivity of the TFC nanofiltration membranes by weakening the controllability of the selective layer structure. Therefore, this study was designed to improve the structural quality of the TFC nanofiltration membranes through surface and interface engineering, and subsequently, increase the functionality.
ALBUQUERQUE, N.M. — A team at Sandia National Laboratories is developing materials to tackle what has become one of the biggest problems in the world: human exposure to a group of chemicals known as PFAS through contaminated water and other products. Sandia is now investing more money to take their research to the next level.
“It’s in the news constantly. It seems every day we hear of another product that is contaminated. We saw sparkling water with PFAS, toilet paper with PFAS, so it’s not just a groundwater problem; it’s popping up everywhere,” said Andrew Knight, a chemist at Sandia who has a passion for solving PFAS contamination. “It has become clear to the world it is a growing problem. It is a national security issue of a large scale.”
PFAS, an abbreviation for perfluoroalkyl and polyfluoroalkyl substances, are a group of chemicals used to make fluoropolymer products that resist heat, oil, stains and water. They are also known as “forever chemicals” because they do not break down in the environment but can move through soil and water and build up in wildlife and humans.
Researchers have used a machine learning model to identify three compounds that could combat aging. They say their approach could be an effective way of identifying new drugs, especially for complex diseases.
Cell division is necessary for our body to grow and for tissues to renew themselves. Cellular senescence describes the phenomenon where cells permanently stop dividing but remain in the body, causing tissue damage and aging across body organs and systems.
Ordinarily, senescent cells are cleared from the body by our immune system. But, as we age, our immune system is less effective at clearing out these cells and their number increases. An increase in senescent cells has been associated with diseases such as cancer, Alzheimer’s disease and the hallmarks of aging such as worsening eyesight and reduced mobility. Given the potentially deleterious effects on the body, there has been a push to develop effective senolytics, compounds that clear out senescent cells.
