Lifeboat Foundation

This is a good use of AI. Definitely regular it but I can see it’s contributing to medical research.

Summary: Researchers have utilized artificial intelligence to uncover the promising potential of extra virgin olive oil (EVOO) in combating Alzheimer’s disease (AD).

By integrating AI, chemistry, and omics research, the study identified specific bioactive compounds in EVOO that could contribute to the treatment and prevention of AD. Ten phytochemicals within EVOO, such as quercetin, genistein, luteolin, and kaempferol, were found to exhibit potential impacts on AD protein networks.

Continue reading “AI Unlocks Olive Oil’s Potential in Alzheimer’s Battle” »

In some deep subterranean aquifers, cells have a chemical trick for making oxygen that could sustain whole underground ecosystems.

Year 2022 😗😁

Better chemistry through computing: #ILLINOIS researchers led an international team that combined powerful AI and a molecule-making machine to automate complex chemistry.

A potent anti-cancer therapy has been created using Nobel prize-winning “click chemistry,” where molecules click together like LEGO bricks, in a new study by UCL and Stanford University researchers.

The study, published in Nature Chemistry, opens up new possibilities for how cutting-edge cancer immunotherapies might be built in future.

The research team created an anti-cancer therapy with three components: one targeting the cancer cell, another recruiting a white blood cell called a T cell to attack the cancer cell, and a third knocking out part of the cancer cell’s defenses.

Microscopic materials made of clay, designed by researchers at the University of Missouri, could be key to the future of synthetic materials chemistry. By enabling scientists to produce chemical layers tailor-made to deliver specific tasks based on the goals of the individual researcher, these materials, called nanoclays, can be used in a wide variety of applications, including the medical field or environmental science.

A paper describing this research is published in the journal ACS Applied Engineering Materials.

A fundamental part of the material is its electrically charged surface, said Gary Baker, co-principal investigator on the project and an associate professor in the Department of Chemistry.

This video, which is a part of the Distinguished Lecture Series by Trivedi School of Biosciences, Ashoka University, Prof. Jack W. Szostak discusses why life began with RNA. Why was Ribose sugar chosen in the primordial soup, and not several other alternative sugars that may have been available? He shows this using elegant experiments that include chemistry and structural biology.

Distinguished Speaker: Prof. Jack W. Szostak.
2009 Nobel Laureate in Physiology or Medicine.

Continue reading “Distinguished Lecture Series | Why life began with RNA | Trivedi School of Biosciences” »

Nobel laureate Jack Szostak from University of Chicago delivered the Eyring General Lecture on March 17, 2023 at Arizona State University. Please click here to learn more about Dr. Szosta and the distinguished Eyring Lecture Series at ASU. https://news.asu.edu/20230309-nobel-laureate-jack-szostak-de…series-asu.

#chemistry #research @arizonastateuniversity @ASUNews

Resistance to current cancer treatments is an important problem that arises through various mechanisms, but one that stands out involves an overexpression of several factors associated with DNA repair. To counteract this type of resistance, different drugs have been developed to affect one or more DNA repair pathways, therefore, to test different compounds of natural origin that have been shown to induce cell death in cancer cells is paramount. Since natural compounds target components of the DNA repair pathways, they have been shown to promote cancer cells to be resensitized to current treatments. For this and other reasons, natural compounds have aroused great curiosity and several research projects are being developed around the world to establish combined treatments between them and radio or chemotherapy. In this work, we summarize the effects of different natural compounds on the DNA repair mechanisms of cancer cells and emphasize their possible application to re-sensitize these cells.

Day by day we are exposed to chemical carcinogens in the environment, ultraviolet (UV) radiation, ionizing radiation, and also those substances produced in our body during cellular metabolism that attack and produce a variety of DNA injuries. Each lesion favors the development of alterations in DNA and chromosomes, which favors oncogenic transformation and tumor progression. In order to reduce the number of changes in the genome and its instability, cells have several pathways of response to damage and DNA repair proteins that eliminate these lesions. DNA adducts, such as those created by alkylating agents, can be cleaved and repaired by base excision repair (BER) or by nucleotide excision repair (NER), depending on whether it is necessary to remove only a nitrogenous base or a nucleotide. Also, O-6-methylguanine-DNA methyltransferase (MGMT), an alkyltransferase, eliminates alkylations.

Scientists specializing in chemical and environmental engineering at the University of California, Riverside have discovered two types of bacteria in the soil capable of breaking down a class of stubborn “forever chemicals,” giving hope for low-cost biological cleanup of industrial pollutants.

Assistant Professor Yujie Men and her team at the Bourns College of Engineering have found that these bacteria are able to eradicate a specific subgroup of per-and poly-fluoroalkyl substances, known as PFAS, particularly those that contain one or more chlorine atoms within their chemical structure. Their findings were published in the scientific journal, Nature Water.

Unhealthful forever chemicals persist in the environment for decades or much longer because of their unusually strong carbon-to-fluorine bonds. Remarkably, the UCR team found that the bacteria cleave the pollutant’s chlorine-carbon bonds, which starts a chain of reactions that destroy the forever chemical structures, rendering them harmless.