Lifeboat Foundation

Research from the University of California, Irvine has revealed how disruption of the circadian clock, the body’s internal, 24-hour biological pacemaker, may accelerate the progression of colorectal cancer by affecting the gut microbiome and intestinal barrier function. This discovery offers new avenues for prevention and treatment strategies.

The study, published online today in the journal Science Advances, offers a more comprehensive understanding of how important changes occur in the function and composition of the gut microbiome when the circadian clock is disturbed in the presence of colorectal cancer.

“There is an alarming rise in early-onset colorectal cancer in adults under the age of 50,” said corresponding author Selma Masri, associate professor of biological chemistry. “Circadian misalignment through extended light exposure, late-night meals and other environmental factors could [be] driving these cases. Our study suggests that clock disruption, particularly through lifestyle choices, may play a significant role in gut health and, subsequently, cancer risk.”

An international team of neuroscientists, led by Duke-NUS Medical School, have uncovered a mechanism that controls the reactivation of neural stem cells, which are crucial for repairing and regenerating brain cells.

The research, published in Nature Communications, offers exciting potential for advancing our understanding and treatment of common neurodegenerative diseases like Alzheimer’s and Parkinson’s disease.

Neural stem cells are the source of the brain’s primary functional cells. After the initial development of the brain, neural stem cells typically enter a dormant state, conserving energy and resources. They re-awaken only when the brain needs them, such as after an injury or with physical exercise.

How do plants and fungi communicate with each other? This is what a recent study published in Molecular Cell hopes to address as an international team of researchers investigated the “language” conducted between plants and fungi that enables fungi growth. This study holds the potential to help scientists and farmers better understand how to fight disease-causing fungi by growing crops with greater resilience and adversity.

“As we begin to understand how plants and fungi communicate, we will better understand the complexities of the soil ecosystem, leading to healthier crops and improving our approach to biodiversity,” said Dr. Shelley Lumba, who is an assistant professor in the Department of Cell and Systems Biology at the University of Toronto and a co-author on the study.

For the study, the researchers examined strigolactone (SL), which is a class of plant hormones and signaling molecules responsible for plant development, with the team focusing on how SL influences fungi growth and development by testing SL with yeast. In the end, the researchers found that SL triggered certain genes called “PHO” that are responsible for phosphate metabolism, along with finding that plants release SL when they are low on phosphate, forcing the yeast to alter the amount of phosphate consumes by triggering the protein, Pho84.

Australian, American and British researchers conducted a prospective analysis of light levels in almost 89 thousand people and concluded that more light exposure at night and less during the day are associated with an increased risk of death from all causes.

Light enhances or disrupts circadian rhythms, depending on the timing of exposure. Circadian disruption contributes to poor health outcomes that increase mortality risk. Whether personal light exposure predicts mortality risk has not been established. We therefore investigated whether personal day and night light, and light patterns that disrupt circadian rhythms, predicted mortality risk. UK Biobank participants (N = 88,905, 62.4 ± 7.8 y, 57% female) wore light sensors for 1 wk. Day and night light exposures were defined by factor analysis of 24-h light profiles. A computational model of the human circadian pacemaker was applied to model circadian amplitude and phase from light data. Cause-specific mortality was recorded in 3,750 participants across a mean (±SD) follow-up period of 8.0 ± 1.0 y.

Women worldwide could see better treatment with new AI technology, which enables better detection of damaged cells and more precisely predicts the risk of getting breast cancer, shows new research from the University of Copenhagen.

Breast cancer is one of the most common types of cancer. In 2022, the disease caused 670,000 deaths worldwide. Now, a new study from the University of Copenhagen shows that AI can help women with improved treatment by scanning for irregular-looking cells to give better risk assessment.

The study, published in The Lancet Digital Health, found that the AI technology was far better at predicting the risk of cancer than current clinical benchmarks for breast cancer risk assessment.

Exposure to certain pollutants, like fine particles (PM2.5) and nitrogen oxides (NOx), during pregnancy and childhood is associated with differences in the microstructure of the brain´s white matter, and some of these effects persist throughout adolescence. These are the main conclusions of a study led by the Barcelona Institute for Global Health (ISGlobal), a centre supported by “la Caixa” Foundation. The findings, published in Environmental Research, highlight the importance of addressing air pollution as a public health issue, particularly for pregnant women and children.

An increasing amount of evidence suggests that air pollution affects neurodevelopment in children. Recent studies using imaging techniques have looked at the impact of air pollutants on the brain’s white matter, which plays a crucial role in connecting different brain regions. However, these studies were limited in that they only looked at one timepoint and did not follow the participants throughout childhood.

“Following participants throughout childhood and including two neuroimaging assessments for each child would shed new light on whether the effects of air pollution on white matter persist, attenuate, or worsen,” says ISGlobal researcher Mònica Guxens. And that is what she and her team did.

An achievement that was deemed impossible has successfully become accomplished. For the first time in history, DNA can be edited. One of the goals is to be able to get rid of genetic diseases. This whole concept in genomic science has opened up a whole new revolutionary way of dealing with such critical health issues. There is a possibility that illnesses that were once incurable have a chance to be curable.

MedlinePlus provides a definition and states that a collection of tools known as genome editing, or gene editing, allows researchers to alter an organism’s DNA. These technologies enable the addition, deletion, or modification of genetic material at specific genomic regions. A person’s DNA can be altered through gene editing to fix mistakes that lead to illnesses.

CRISPR-Cas9, short for CRISPR-associated protein 9 and clustered regularly interspaced short palindromic repeats, is a well-known example as one of the approaches used and developed by scientists to edit DNA. The scientific community is very excited about the CRISPR-Cas9 system since it is more accurate, efficient, quicker, and less expensive than existing genome editing techniques.

(Nanowerk Spotlight) In the world of athletic performance and outdoor sports, the gear athletes wear can make or break their ability to perform.

Smart nanofabric integrates impact protection, real-time health monitoring, and radiative cooling into a lightweight, durable textile for advanced sportswear.

My name is Asim, Global Product Marketing Lead for Peridot, and I’m excited to share some news about our Peridot franchise that I’m incredibly passionate about.

Virtual pets have long been a source of fun and entertainment. But what if they could help us recover from injuries and illnesses, too?

Today we’re announcing our partnership with Augment Therapy, a digital health company building accessible immersive exercise software for healthcare. Together, we aim to help people recover from injuries and illnesses faster by creating new Peridot-inspired experiences for physical rehabilitation use cases in pediatric and geriatric care. What makes this partnership truly exceptional is our shared vision: leveraging cutting-edge technology to encourage movement and promote well-being.