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Researchers from Zhejiang University, Kunming Institute of Zoology, Northwest University, and Yunnan University, Aarhus University, and BGI-Research have jointly led a series of significant new studies are published in a special issue of the journal Science, and in papers in Nature Ecology & Evolution and Science Advances.

Co-led by Guojie Zhang from Centre for Evolutionary & Organismal Biology at Zhejiang University, Dong-Dong Wu at Kunming Institute of Zoology, Xiao-Guang Qi at Northwest University, Li Yu at Yunnan University, Mikkel Heide Schierup at Aarhus University, and Yang Zhou at BGI-Research, the Primate Genome Consortium reported a series of publications from its first phase program. The program includes high quality reference genomes from 50 primate species, of which 27 were sequenced for the first time. These studies provide new insights on the speciation process, genomic diversity, social evolution, sex chromosomes, and the evolution of the brain and other biological traits.

The comparative analysis of primate genomes within a phylogenetic context is crucial for understanding the evolution of the human genetic architecture and the inter-species genomic differences associated with primate diversification. Previous studies of primate genomes have focused mainly on primate species closely related to humans and were constrained by the lack of broader phylogenetic coverage.

Science can’t stop aging, but it may be able to slow our epigenetic clocks.

The lone volunteer in a gene-editing study targeting a rare form of Duchenne muscular dystrophy likely died after having a reaction to the virus that delivered the therapy in his body, researchers concluded in an early study.

Terry Horgan, 27, of Montour Falls, New York, died last year during one of the first tests of a gene-editing treatment designed for one person. Some scientists wondered if the gene-editing tool CRISPR played a part in his death. The tool has transformed genetic research, sparked the development of dozens of experimental drugs, and won its inventors the Nobel Prize in 2020.

But researchers said the virus — one used to carry treatment into the body because it doesn’t usually make people sick — combined with his condition, triggered the problems that ultimately killed him.

Jo Cameron is a 75-year-old Scottish woman who has gone through life without experiencing significant pain of any kind. Even major surgery and childbirth failed to deliver the discomfort most of us would experience.

According to an interview with the BBC in 2019, Cameron only knows her skin is burning if she smells or sees it. To her, suffering is nothing more than an abstract concept.

The quirk that Cameron was born with is shared with just a few other people in th e world. Called congenital analgesia, it is a one-in-a-million condition with multiple genetic causes that may come with other symptoms, such as sweating more or having no sense of smell.

Geneticists have unearthed a major event in the ancient history of sturgeons and paddlefish that has significant implications for the way we understand evolution. They have pinpointed a previously hidden “whole genome duplication” (WGD) in the common ancestor of these species, which seemingly opened the door to genetic variations that may have conferred an advantage around the time of a major mass extinction some 200 million years ago.

The big-picture finding suggests that there may be many more overlooked, shared WGDs in other species before periods of extreme environmental upheaval throughout Earth’s tumultuous history.

The research, led by Professor Aoife McLysaght and Dr. Anthony Redmond from Trinity College Dublin’s School of Genetics and Microbiology, has just been published in Nature Communications.

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The root cause is frustratingly simple: one gene mutation, which affects a critical protein that helps support skin integrity. The single genetic error makes the illness a perfect candidate for gene therapy. Yet with the skin already fragile, injections—a current standard for gene therapy—are hard to tolerate.

What about a genetic moisturizer instead?

This month, the FDA approved the first rub-on gene therapy. Similar to aloe vera for treating sunburns, the therapy comes in a gel that’s gently massaged onto blisters and wounds to help with healing. Dubbed Vyjuvek, it directly delivers healthy copies of the mutated gene onto damaged skin. An alternative version is configured into eye drops to reconstruct the eye’s delicate architecture to better support sight.

‘Base editors’ fix specific sites in the genome without cutting the DNA double helix, according to team.

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In the pursuit of extending healthy human lifespans, scientists have achieved a remarkable breakthrough that marks a significant milestone in the field. Researchers from Taipei Medical University in Taiwan have uncovered a genetic modification in mice that can empower cancer-killing cells, increasing their effectiveness by two to seven times while extending their lifespan by up to 20 percent.

Building upon last year’s groundbreaking study, the scientists have now successfully replicated these extraordinary outcomes in ordinary mice through a single transplant of blood stem cells. The findings, published in the scientific journal Cold Spring Harbor Protocols, hold immense importance, according to Che-Kun James Shen, the lead researcher of the study. He believes that these findings could have profound implications for human health and anticipates that clinical trials could commence as early as the end of this year or next year.

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